As the launch of fifth generation (5G) wireless networks is approaching, recent years have witnessed comprehensive discussions about a possible 5G standard. Many transmission scenarios and technologies have been proposed and initial over-the-air experimental trials have been conducted. Most of the existing literature studies on 5G technologies have mainly focused on the physical layer parameters and quality of service (QoS) requirements, e.g., achievable data rates. However, the demand for delay-sensitive data traffic over wireless networks has increased exponentially in the recent years, and is expected to further increase by the time of 5G. Therefore, other constraints at the data-link layer concerning the buffer overflow and delay violation probabilities should also be regarded. It follows that evaluating the performance of the 5G technologies when such constraints are considered is a timely task. Motivated by this fact, in this thesis we explore the performance of three promising 5G technologies when operating under certain QoS at the data-link layer. We follow a cross-layer approach to examine the interplay between the physical and data-link layers when statistical QoS constraints are inflicted in the form of limits on the delay violation and buffer overflow probabilities. Noting that wireless systems, generally, have limited physical resources, in this thesis we mainly target designing adaptive resource allocation schemes to maximize the system performance under such QoS constraints. We initially investigate the throughput and energy efficiency of a general class of multiple-input multiple-output (MIMO) systems with arbitrary inputs. As a cross-layer evaluation tool, we employ the effective capacity as the main performance metric, which is the maximum constant data arrivalrate at a buffer that can be sustained by the channel service process under specified QoS constraints. We obtain the optimal input covariance matrix that maximizes the effective capacity under a short-term average power budget. Then, we perform an asymptotic analysis of the effective capacity in the low signal-to-noise ratio and large-scale antenna (massive MIMO) regimes. Such analysis has a practical importance for 5G scenarios that necessitate low latency, low power consumption, and/or ability to simultaneously support massive number of users. Non-orthogonal multiple access (NOMA) has attracted significant attention in the recent years as a promising multiple access technology for 5G. In this thesis, we consider a two-user power-domain NOMA scheme in which both transmitters employ superposition coding and the receiver applies successive interference cancellation (SIC) with a certain order. For practical concerns, we consider limited transmission power budgets at the transmitters, and assume that both transmitters have arbitrarily distributed input signals. We again exploit the effective capacity as the main cross-layer performance measure. We provide a resource management scheme that can jointly obtain the optimal power allocation policies at the transmitters and the optimal decoding order at the receiver, with the goal of maximizing the effective capacity region that provides the maximum allowable sustainable arrival rate region at the transmitters' buffers under QoS guarantees.In the recent years, visible light communication (VLC) has emerged as a potential transmission technology that can utilize the visible light spectrum for data transmission along with illumination. Different from the existing literature studies on VLC, in this thesis we consider a VLC system in which the access point (AP) is unaware of the channel conditions, thus the AP sends the data at a fixed rate. Under this assumption, and considering an ON-OFF data source, we provide a cross-layer study when the system is subject to statistical buffering constraints. To this end, we employ the maximum average data arrival rate at the AP buffer and the non-asymptotic bounds on buffering delay as the main performance measures. To facilitate our analysis, we adopt a two-state Markov process to model the fixed-rate transmission strategy, and we then formulate the steady-state probabilities of the channel being in the ON and OFF states. The coexistence of radio frequency (RF) and VLC systems in typical indoor environments can be leveraged to support vast user QoS needs. Inthis thesis, we examine the benefits of employing both technologies when operating under statistical buffering limitations. Particularly, we consider a multi-mechanism scenario that utilizes RF and VLC links for data transmission in an indoor environment. As the transmission technology is the main physical resource to be concerned in this part, we propose a link selection process through which the transmitter sends data over the link that sustains the desired QoS guarantees the most. Considering an ON-OFF data source, we employ the maximum average data arrival rate at the transmitter buffer and the non-asymptotic bounds on data buffering delay as the main performance measures. We formulate the performance measures under the assumption that both links are subject to average and peak power constraints.