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Hildebrandt, Tatjana: Amino acid catabolism in plants. Hannover : Gottfried Wilhelm Leibniz Universität, Habil.-Schr., 2019, 30 S. DOI:

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Sum total of downloads: 643

Amino acids are among the most versatile compounds in plants performing diverse functions within proteins as well as individually. The publications constituting this habilitation thesis focus on different aspects of amino acid catabolism. Not all of the biochemical pathways catalyzing degradation of the twenty proteinogenic amino acids in plants are known, and annotation of amino acid catabolic enzymes in databases and pathway maps is still insufficient for comprehensive evaluation of proteomics or transcriptomics datasets. Thus, a manually assembled pathway map covering 136 reactions involved in amino acid related pathways is presented and used for reevaluation of already published as well as interpretation of new omics datasets. This approach clearly defines gaps in the present knowledge and at the same time postulates candidate proteins for unknown reactions as a starting point for further investigation. In addition, it provides insight into the different metabolic functions of amino acid catabolism and their significance during abiotic and biotic stress response. A major topic of the work presented here is cysteine catabolism. Cysteine in addition to the amino group also contains a thiol moiety and therefore represents an intersection of carbon, nitrogen and sulfur metabolism. The degradation of cysteine via different enzymatic routes releases reduced sulfur in the form of sulfide or persulfide, which act as signaling molecules and can be further metabolized either by reincorporation into cysteine or by oxidation. This thesis describes a mitochondrial cysteine catabolic pathway that oxidizes the thiol group catalyzed by the sulfur dioxygenase ETHE1. In plants, this pathway is essential during early embryo development and also required for energy metabolism during low light availability. Mutations in the ETHE1 gene in humans cause the metabolic disease ethylmalonic encephalopathy, which is characterized by rapidly progressive encephalopathy, chronic diarrhea, and peripheral microangio¬pathy caused by accumulation of toxic sulfide levels. These symptoms can be relieved by combined treatment with a bactericide that represses sulfide production by intestinal anaerobes and N-acetylcysteine as a precursor for glutathione, which can act as a buffer for reduced sulfur.
License of this version: Es gilt deutsches Urheberrecht. Das Dokument darf zum eigenen Gebrauch kostenfrei genutzt, aber nicht im Internet bereitgestellt oder an Außenstehende weitergegeben werden.
Document Type: DoctoralThesis
Publishing status: publishedVersion
Issue Date: 2019
Appears in Collections:Naturwissenschaftliche Fakultät

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pos. country downloads
total perc.
1 image of flag of Germany Germany 265 41.21%
2 image of flag of United States United States 75 11.66%
3 image of flag of India India 53 8.24%
4 image of flag of Russian Federation Russian Federation 18 2.80%
5 image of flag of Egypt Egypt 15 2.33%
6 image of flag of Pakistan Pakistan 13 2.02%
7 image of flag of No geo information available No geo information available 12 1.87%
8 image of flag of Iran, Islamic Republic of Iran, Islamic Republic of 11 1.71%
9 image of flag of Indonesia Indonesia 10 1.56%
10 image of flag of Czech Republic Czech Republic 10 1.56%
    other countries 161 25.04%

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