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Download statistics - Document (COUNTER):
Knobloch, Tobias; Dräger, Gerald; Collisi, W.; Sasse, F.; Kirschning, Andreas: Unprecedented deoxygenation at C-7 of the ansamitocin core during mutasynthetic biotransformations. In: Beilstein Journal of Organic Chemistry 8 (2012), S. 861-869. DOI: http://dx.doi.org/10.3762/bjoc.8.96
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Sum total of downloads: 126
| Abstract: | |
We describe the unprecedented formation of six ansamitocin derivatives that are deoxygenated at C-7 of the ansamitocin core, obtained during fermentation experiments by employing a variety of Actinosynnema pretiosum mutants and mutasynthetic approaches. We suggest that the formation of these derivatives is based on elimination at C-7/C-8 followed by reduction(s) of the intermediate enone. In bioactivity tests, only ansamitocin derivatives bearing an ester side chain at C-3 showed strong antiproliferative activity. | |
| License of this version: | CC BY 2.0 Unported |
| Document Type: | Article |
| Publishing status: | publishedVersion |
| Issue Date: | 2012 |
| Appears in Collections: | Naturwissenschaftliche Fakultät |
distribution of downloads over the selected time period:
downloads by country:
| pos. | country | downloads | ||
|---|---|---|---|---|
| total | perc. | |||
| 1 |  |
Germany | 90 | 71.43% |
| 2 |  |
United States | 19 | 15.08% |
| 3 |  |
China | 9 | 7.14% |
| 4 |  |
Taiwan | 1 | 0.79% |
| 5 |  |
Saudi Arabia | 1 | 0.79% |
| 6 |  |
Russian Federation | 1 | 0.79% |
| 7 |  |
Netherlands | 1 | 0.79% |
| 8 |  |
Kenya | 1 | 0.79% |
| 9 |  |
Canada | 1 | 0.79% |
| 10 |  |
Austria | 1 | 0.79% |
| other countries | 1 | 0.79% | ||
Further download figures and rankings:
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