Regulation of lipid metabolism-related gene expression in whole blood cells of normo- and dyslipidemic men after fish oil supplementation

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Schmidt, Simone; Willers, Janina; Stahl, Frank; Mutz, Kai-Oliver; Scheper, Thomas et al.: Regulation of lipid metabolism-related gene expression in whole blood cells of normo- and dyslipidemic men after fish oil supplementation. In: Lipids in Health and Disease 11 (2012), 172. DOI:

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Background: Beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on the lipid levels of dyslipidemic subjects are widely described in the literature. However, the underlying molecular mechanisms are largely unknown. The aim of this study was to investigate the effects of n-3 PUFAs on the expression of lipid metabolism-related genes in normo- and dyslipidemic men to unveil potential genes and pathways affecting lipid metabolism. Methods. Ten normo- and ten dyslipidemic men were supplemented for twelve weeks with six fish oil capsules per day, providing 1.14 g docosahexaenoic acid and 1.56 g eicosapentaenoic acid. The gene expression levels were determined by whole genome microarray analysis and quantitative real-time polymerase chain reaction. Results: Several transcription factors (peroxisome proliferator-activated receptor α (PPARα), retinoid X receptor (RXR) α, RXRγ, hepatic nuclear factor (HNF) 6, and HNF1ß) as well as other genes related to triacylglycerol (TG) synthesis or high-density lipoprotein (HDL-C) and cholesterol metabolism (phospholipids transfer protein, ATP-binding cassette sub-family G member 5, 2-acylglycerol O-acyltransferase (MOGAT) 3, MOGAT2, diacylglycerol O-acyltransferase 1, sterol O-acyltransferase 1, apolipoprotein CII, and low-density lipoprotein receptor) were regulated after n-3 PUFA supplementation, especially in dyslipidemic men. Conclusion: Gene expression analyses revealed several possible molecular pathways by which n-3 PUFAs lower the TG level and increase the HDL-C and low-density lipoprotein level, whereupon the regulation of PPARα appear to play a central role. Trial registration. (ID: NCT01089231).
License of this version: CC BY 2.0
Document Type: article
Publishing status: publishedVersion
Issue Date: 2012
Appears in Collections:Naturwissenschaftliche Fakultät

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1 image of flag of Germany Germany 83 79.05%
2 image of flag of China China 9 8.57%
3 image of flag of Malaysia Malaysia 3 2.86%
4 image of flag of No geo information available No geo information available 2 1.90%
5 image of flag of France France 2 1.90%
6 image of flag of Russian Federation Russian Federation 1 0.95%
7 image of flag of Europe Europe 1 0.95%
8 image of flag of Canada Canada 1 0.95%
9 image of flag of Brazil Brazil 1 0.95%
10 image of flag of Bosnia and Herzegovina Bosnia and Herzegovina 1 0.95%
    other countries 1 0.95%

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