Evaluation of the soft tissue biocompatibility of MgCa0.8 and surgical steel 316L in vivo: A comparative study in rabbits

Download statistics - Document (COUNTER):

Erdmann, N.; Bondarenko, A.; Hewicker-Trautwein, M.; Angrisani, N.; Reifenrath, J.et al.: Evaluation of the soft tissue biocompatibility of MgCa0.8 and surgical steel 316L in vivo: A comparative study in rabbits. In: BioMedical Engineering Online 9 (2010), 63. DOI: http://dx.doi.org/10.1186/1475-925X-9-63

Repository version

To cite the version in the repository, please use this identifier: https://doi.org/10.15488/595

Selected time period:

year: 
month: 

Sum total of downloads: 340




Thumbnail
Abstract: 
Background: Recent studies have shown the potential suitability of magnesium alloys as biodegradable implants. The aim of the present study was to compare the soft tissue biocompatibility of MgCa0.8 and commonly used surgical steel in vivo.Methods: A biodegradable magnesium calcium alloy (MgCa0.8) and surgical steel (S316L), as a control, were investigated. Screws of identical geometrical conformation were implanted into the tibiae of 40 rabbits for a postoperative follow up of two, four, six and eight weeks. The tibialis cranialis muscle was in direct vicinity of the screw head and thus embedded in paraffin and histologically and immunohistochemically assessed. Haematoxylin and eosin staining was performed to identify macrophages, giant cells and heterophil granulocytes as well as the extent of tissue fibrosis and necrosis. Mouse anti-CD79α and rat anti-CD3 monoclonal primary antibodies were used for B- and T-lymphocyte detection. Evaluation of all sections was performed by applying a semi-quantitative score.Results: Clinically, both implant materials were tolerated well. Histology revealed that a layer of fibrous tissue had formed between implant and overlying muscle in MgCa0.8 and S316L, which was demarcated by a layer of synoviocyte-like cells at its interface to the implant. In MgCa0.8 implants cavities were detected within the fibrous tissue, which were surrounded by the same kind of cell type. The thickness of the fibrous layer and the amount of tissue necrosis and cellular infiltrations gradually decreased in S316L. In contrast, a decrease could only be noted in the first weeks of implantation in MgCa0.8, whereas parameters were increasing again at the end of the observation period. B-lymphocytes were found more often in MgCa0.8 indicating humoral immunity and the presence of soluble antigens. Conversely, S316L displayed a higher quantity of T-lymphocytes.Conclusions: Moderate inflammation was detected in both implant materials and resolved to a minimum during the first weeks indicating comparable biocompatibility for MgCa0.8 and S316L. Thus, the application of MgCa0.8 as biodegradable implant material seems conceivable. Since the inflammatory parameters were re-increasing at the end of the observation period in MgCa0.8 it is important to observe the development of inflammation over a longer time period in addition to the present study.
License of this version: CC BY 2.0
Document Type: article
Publishing status: publishedVersion
Issue Date: 2010
Appears in Collections:Fakultät für Maschinenbau

distribution of downloads over the selected time period:

downloads by country:

pos. country downloads
total perc.
1 image of flag of Germany Germany 309 90.88%
2 image of flag of United Kingdom United Kingdom 18 5.29%
3 image of flag of No geo information available No geo information available 2 0.59%
4 image of flag of United States United States 2 0.59%
5 image of flag of Russian Federation Russian Federation 2 0.59%
6 image of flag of Taiwan Taiwan 1 0.29%
7 image of flag of Netherlands Netherlands 1 0.29%
8 image of flag of Italy Italy 1 0.29%
9 image of flag of Indonesia Indonesia 1 0.29%
10 image of flag of France France 1 0.29%
    other countries 2 0.59%

Further download figures and rankings:


Hinweis

Zur Erhebung der Downloadstatistiken kommen entsprechend dem „COUNTER Code of Practice for e-Resources“ international anerkannte Regeln und Normen zur Anwendung. COUNTER ist eine internationale Non-Profit-Organisation, in der Bibliotheksverbände, Datenbankanbieter und Verlage gemeinsam an Standards zur Erhebung, Speicherung und Verarbeitung von Nutzungsdaten elektronischer Ressourcen arbeiten, welche so Objektivität und Vergleichbarkeit gewährleisten sollen. Es werden hierbei ausschließlich Zugriffe auf die entsprechenden Volltexte ausgewertet, keine Aufrufe der Website an sich.

Search the repository


Browse