Sub-structures of offshore wind turbines are designed according to several design load cases (DLCs) that cover various fatigue (FLS) and ultimate limit states (ULS). The required DLCs are given in the current standards, and are supposed, on the one hand, to cover accurately all significant load conditions to guarantee reliability. On the other hand, they should include only necessary conditions to keep computing times manageable. For ULS conditions, the current work addresses the question whether the current design practice is, firstly, sufficient, and secondly, sensible concerning the computing time by only including necessary DLCs. To address this topic, data of five years of normal operation, simulated using a probabilistic approach, is used to extrapolate 20-year ULS loads (comparable to a probabilistic version of DLC 1.1 for substructures). These ULS values are compared to several deterministic DLCs required by current standards. Results show that probabilistic, extrapolated ULS values are fairly high and exceed standard DLC loads. Hence, the current design practice might not always be conservative. Especially, the benefit of an additional DLC for wave peak periods close to the eigenfrequency of the sub-structure is indicated.