TFG Promotes Organization of Transitional ER and Efficient Collagen Secretion

Download statistics - Document (COUNTER):

McCaughey, Janine; Miller, Victoria J.; Stevenson, Nicola L.; Brown, Anna K.; Budnik, Annika et al.: TFG Promotes Organization of Transitional ER and Efficient Collagen Secretion. In: Cell Reports 15 (2016), Nr. 8, S. 1648-1659. DOI: http://dx.doi.org/10.1016/j.celrep.2016.04.062

Repository version

To cite the version in the repository, please use this identifier: https://doi.org/10.15488/500

Selected time period:

year: 
month: 

Sum total of downloads: 130




Thumbnail
Abstract: 
Collagen is the most abundant protein in the animal kingdom. It is of fundamental importance during development for cell differentiation and tissue morphogenesis as well as in pathological processes such as fibrosis and cancer cell migration. However, our understanding of the mechanisms of procollagen secretion remains limited. Here, we show that TFG organizes transitional ER (tER) and ER exit sites (ERESs) into larger structures. Depletion of TFG results in dispersion of tER elements that remain associated with individual ER-Golgi intermediate compartments (ERGICs) as largely functional ERESs. We show that TFG is not required for the transport and packaging of small soluble cargoes but is necessary for the export of procollagen from the ER. Our work therefore suggests a key relationship between the structure and function of ERESs and a central role for TFG in optimizing COPII assembly for procollagen export.
License of this version: CC BY 4.0 Unported
Document Type: article
Publishing status: publishedVersion
Issue Date: 2016
Appears in Collections:Naturwissenschaftliche Fakultät

distribution of downloads over the selected time period:

downloads by country:

pos. country downloads
total perc.
1 image of flag of Germany Germany 95 73.08%
2 image of flag of United States United States 11 8.46%
3 image of flag of France France 7 5.38%
4 image of flag of Indonesia Indonesia 3 2.31%
5 image of flag of Vietnam Vietnam 2 1.54%
6 image of flag of No geo information available No geo information available 2 1.54%
7 image of flag of Australia Australia 2 1.54%
8 image of flag of Hungary Hungary 1 0.77%
9 image of flag of United Kingdom United Kingdom 1 0.77%
10 image of flag of Estonia Estonia 1 0.77%
    other countries 5 3.85%

Further download figures and rankings:


Hinweis

Zur Erhebung der Downloadstatistiken kommen entsprechend dem „COUNTER Code of Practice for e-Resources“ international anerkannte Regeln und Normen zur Anwendung. COUNTER ist eine internationale Non-Profit-Organisation, in der Bibliotheksverbände, Datenbankanbieter und Verlage gemeinsam an Standards zur Erhebung, Speicherung und Verarbeitung von Nutzungsdaten elektronischer Ressourcen arbeiten, welche so Objektivität und Vergleichbarkeit gewährleisten sollen. Es werden hierbei ausschließlich Zugriffe auf die entsprechenden Volltexte ausgewertet, keine Aufrufe der Website an sich.

Search the repository


Browse