Comparison of two prototypes of a magnetically adjustable glaucoma implant in rabbits

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Schwerk, B.; Harder, L.; Windhövel, C.; Hewicker-Trautwein, M.; Wagner, A. et al.: Comparison of two prototypes of a magnetically adjustable glaucoma implant in rabbits. In: PLoS ONE 14 (2019), Nr. 4, e0215316. DOI:

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Sum total of downloads: 101

Glaucoma drainage devices are used in surgical glaucoma therapy. Success of controlling the intraocular pressure is limited due to fibrous implant encapsulation and fibrin coating on the implant which lead to drainage obstructions. An innovative implant with a magnetically adjustable valve was developed. The valve opening of the implant should eliminate inflammatory products from the outflow area and affect fibrous tissue formation to achieve a sufficient long-term aqueous humour outflow. Lifting of this valve should disturb cell adhesion by exerting mechanical forces. Before testing this hypothesis, the flow characteristics of glaucoma drainage devices, especially the outflow resistance by regular IOP, should be considered in a pilot study, as they are important in preventing too low postoperative intraocular pressure known as ocular hypotony. Therefore, two prototypes of the innovative implant differing in their valve area design were examined regarding their flow characteristics in a limited animal experiment lasting two weeks. Ten healthy New Zealand White rabbits were divided into two groups (A & B) with different implanted prototypes. Daily, tonometry and direct ophthalmoscopy were performed to assess the intraocular pressure and the inflammatory reaction of the eye. After two weeks, the rabbits were euthanised to evaluate the initially histological inflammatory reaction to the implant. In group A, one case of hypotony emerged. When considering the entire observation period, a highly statistically significant difference between the intraocular pressure in the operated eye and that in the control eye was detected in group A (p < 0.0001) in contrast to group B (p = 0.0063). The postoperative inflammatory signs decreased within two weeks. Histologically, a typical but low level foreign body reaction with macrophages and lymphocytes as well as mild to moderate fibrosis was seen after the short experimental period. Based on our tonometric results, prototype B seems to be the system of choice for further research assessing its long-term function and biocompatibility.
License of this version: CC BY 4.0 Unported
Document Type: Article
Publishing status: publishedVersion
Issue Date: 2019
Appears in Collections:Fakultät für Mathematik und Physik

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pos. country downloads
total perc.
1 image of flag of Germany Germany 46 45.54%
2 image of flag of United States United States 25 24.75%
3 image of flag of China China 11 10.89%
4 image of flag of Netherlands Netherlands 3 2.97%
5 image of flag of Nigeria Nigeria 3 2.97%
6 image of flag of No geo information available No geo information available 2 1.98%
7 image of flag of Taiwan Taiwan 1 0.99%
8 image of flag of Philippines Philippines 1 0.99%
9 image of flag of New Zealand New Zealand 1 0.99%
10 image of flag of Japan Japan 1 0.99%
    other countries 7 6.93%

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