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Schueling, T.; Eilers, A.; Scheper, T.; Walter, J.: Aptamer-based lateral flow assays. In: AIMS Bioengineering 5 (2018), Nr. 2, S. 78-102. DOI: https://doi.org/10.3934/bioeng.2018.2.78

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To cite the version in the repository, please use this identifier: https://doi.org/10.15488/4903

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Sum total of downloads: 531




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Abstract: 
Lateral flow assays as point-of-care devices have attracted interest due to their advantages including low costs, easy operation by non-specialized users and low analyte volumes needed. These advantages make lateral flow assays to superior tools for the on-site detection of analytes with qualitative or semi-quantitative results within minutes. Aptamers are single-stranded nucleic acid oligomers with distinct conformational shapes that can bind their corresponding targets via molecular recognition. Due to their specific properties like an efficient chemical synthesis, a longer shelf life and easy introduction of modifications aptamers seem to be ideal biological recognition elements. Moreover, they enable the design of intelligent detection schemes not available with antibodies. This review focuses on lateral flow assays utilizing aptamers as an element for molecular recognition. In the first part of the review, a brief overview on lateral flow assays and aptamers, regarding their generation and properties, will be given. In the second part, a review of recently published literature on this topic will demonstrate the broad spectrum of possible applications and analytes, detectable with aptamer-based lateral flow assays.
License of this version: CC BY 4.0 Unported
Document Type: article
Publishing status: publishedVersion
Issue Date: 2018
Appears in Collections:Naturwissenschaftliche Fakultät

distribution of downloads over the selected time period:

downloads by country:

pos. country downloads
total perc.
1 image of flag of Germany Germany 139 26.18%
2 image of flag of United States United States 62 11.68%
3 image of flag of China China 50 9.42%
4 image of flag of India India 31 5.84%
5 image of flag of Iran, Islamic Republic of Iran, Islamic Republic of 25 4.71%
6 image of flag of Korea, Republic of Korea, Republic of 22 4.14%
7 image of flag of United Kingdom United Kingdom 17 3.20%
8 image of flag of Taiwan Taiwan 14 2.64%
9 image of flag of Turkey Turkey 14 2.64%
10 image of flag of Australia Australia 12 2.26%
    other countries 145 27.31%

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