Effects of Ginkgo biloba in dementia: systematic review and meta-analysis

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Weinmann, S.; Roll, S.; Schwarzbach, C.; Vauth, C.; Willich, S.N.: Effects of Ginkgo biloba in dementia: systematic review and meta-analysis. In: BMC Geriatrics 10 (2010), 14. DOI: https://doi.org/10.1186/1471-2318-10-14

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Sum total of downloads: 129




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Background: The benefit of Ginkgo biloba has been discussed controversially. The aim of this review was to assess the effects of Ginkgo biloba in Alzheimer's disease as well as vascular and mixed dementia covering a variety of outcome domains. Methods: We searched MEDLINE, EMBASE, the Cochrane databases, CINAHL and PsycINFO for controlled trials of ginkgo for Alzheimer's, vascular or mixed dementia. Studies had to be of a minimum of 12 weeks duration with at least ten participants per group. Clinical characteristics and outcomes were extracted. Meta-analysis results were expressed as risk ratios or standardized mean differences (SMD) in scores. Results: Nine trials using the standardized extract EGb761 (R) met our inclusion criteria. Trials were of 12 to 52 weeks duration and included 2372 patients in total. In the meta-analysis, the SMDs in change scores for cognition were in favor of ginkgo compared to placebo (-0.58, 95% confidence interval [CI] -1.14; -0.01, p = 0.04), but did not show a statistically significant difference from placebo for activities in daily living (ADLs) (SMD = -0.32, 95% CI -0.66; 0.03, p = 0.08). Heterogeneity among studies was high. For the Alzheimer subgroup, the SMDs for ADLs and cognition outcomes were larger than for the whole group of dementias with statistical superiority for ginkgo also for ADL outcomes (SMD = -0.44, 95% CI -0.77; -0.12, p = 0.008). Drop-out rates and side effects did not differ between ginkgo and placebo. No consistent results were available for quality of life and neuropsychiatric symptoms, possibly due to the heterogeneity of the study populations. Conclusions: Ginkgo biloba appears more effective than placebo. Effect sizes were moderate, while clinical relevance is, similar to other dementia drugs, difficult to determine.
License of this version: CC BY 4.0 Unported
Document Type: Article
Publishing status: publishedVersion
Issue Date: 2010
Appears in Collections:Forschungszentren

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pos. country downloads
total perc.
1 image of flag of Germany Germany 60 46.51%
2 image of flag of United States United States 47 36.43%
3 image of flag of No geo information available No geo information available 3 2.33%
4 image of flag of Switzerland Switzerland 3 2.33%
5 image of flag of Russian Federation Russian Federation 2 1.55%
6 image of flag of China China 2 1.55%
7 image of flag of Korea, Republic of Korea, Republic of 1 0.78%
8 image of flag of Iran, Islamic Republic of Iran, Islamic Republic of 1 0.78%
9 image of flag of India India 1 0.78%
10 image of flag of Austria Austria 1 0.78%
    other countries 8 6.20%

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