Strobilurin biosynthesis in Basidiomycete fungi

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Nofiani, R.; de Mattos-Shipley, K.; Lebe, K.E.; Han, L.-C.; Iqbal, Z. et al.: Strobilurin biosynthesis in Basidiomycete fungi. In: Nature Communications 9 (2018), Nr. 1, 3940. DOI:

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Sum total of downloads: 110

Strobilurins from fungi are the inspiration for the creation of the β-methoxyacrylate class of agricultural fungicides. However, molecular details of the biosynthesis of strobilurins have remained cryptic. Here we report the sequence of genomes of two fungi that produce strobilurins and show that each contains a biosynthetic gene cluster, which encodes a highly reducing polyketide synthase with very unusual C-terminal hydrolase and methyltransferase domains. Expression of stpks1 in Aspergillus oryzae leads to the production of prestrobilurin A when the fermentation is supplemented with a benzoyl coenzyme A (CoA) analogue. This enables the discovery of a previously unobserved route to benzoyl CoA. Reconstruction of the gene cluster in A. oryzae leads to the formation of prestrobilurin A, and addition of the gene str9 encoding an FAD-dependent oxygenase leads to the key oxidative rearrangement responsible for the creation of the β-methoxyacrylate toxophore. Finally, two methyltransferases are required to complete the synthesis.
License of this version: CC BY 4.0 Unported
Document Type: article
Publishing status: publishedVersion
Issue Date: 2018
Appears in Collections:Naturwissenschaftliche Fakultät

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pos. country downloads
total perc.
1 image of flag of Germany Germany 93 84.55%
2 image of flag of United States United States 6 5.45%
3 image of flag of Russian Federation Russian Federation 2 1.82%
4 image of flag of Pakistan Pakistan 2 1.82%
5 image of flag of Czech Republic Czech Republic 2 1.82%
6 image of flag of Ukraine Ukraine 1 0.91%
7 image of flag of Greece Greece 1 0.91%
8 image of flag of United Kingdom United Kingdom 1 0.91%
9 image of flag of Europe Europe 1 0.91%
10 image of flag of China China 1 0.91%

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