Gold nanoparticle-mediated laser stimulation induces a complex stress response in neuronal cells

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Johannsmeier, S.; Heeger, P.; Terakawa, M.; Kalies, S.; Heisterkamp, A. et al.: Gold nanoparticle-mediated laser stimulation induces a complex stress response in neuronal cells. In: Scientific Reports 8 (2018), Nr. 1, 6533. DOI:

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Sum total of downloads: 156

Stimulation of neuronal cells generally resorts to electric signals. Recent advances in laser-based stimulation methods could present an alternative with superior spatiotemporal resolution. The avoidance of electronic crosstalk makes these methods attractive for in vivo therapeutic application. In particular, nano-mediators, such as gold nanoparticles, can be used to transfer the energy from a laser pulse to the cell membrane and subsequently activate excitable cells. Although the underlying mechanisms of neuronal activation have been widely unraveled, the overall effect on the targeted cell is not understood. Little is known about the physiological and pathophysiological impact of a laser pulse targeted onto nanoabsorbers on the cell membrane. Here, we analyzed the reaction of the neuronal murine cell line Neuro-2A and murine primary cortical neurons to gold nanoparticle mediated laser stimulation. Our study reveals a severe, complex and cell-type independent stress response after laser irradiation, emphasizing the need for a thorough assessment of this approach's efficacy and safety. © 2018 The Author(s).
License of this version: CC BY 4.0 Unported
Document Type: Article
Publishing status: publishedVersion
Issue Date: 2018
Appears in Collections:Fakultät für Mathematik und Physik

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pos. country downloads
total perc.
1 image of flag of Germany Germany 119 76.28%
2 image of flag of United States United States 21 13.46%
3 image of flag of China China 6 3.85%
4 image of flag of No geo information available No geo information available 2 1.28%
5 image of flag of Czech Republic Czech Republic 2 1.28%
6 image of flag of Taiwan Taiwan 1 0.64%
7 image of flag of Korea, Republic of Korea, Republic of 1 0.64%
8 image of flag of Hungary Hungary 1 0.64%
9 image of flag of France France 1 0.64%
10 image of flag of Canada Canada 1 0.64%
    other countries 1 0.64%

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