Phenotypic and Genotypic Characteristics of Members of the Genus Streptobacillus

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Eisenberg, Tobias; Nicklas, Werner; Mauder, Norman; Rau, Joerg; Contzen, Matthias; Semmler, Torsten; Hofmann, Nicola; Aledelbi, Khayrieh; Ewers, Christa: Phenotypic and Genotypic Characteristics of Members of the Genus Streptobacillus. In: PloS ONE 10 (2015), Nr. 8, e0134312. DOI: http://dx.doi.org/10.1371/journal.pone.0134312

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Abstract: 
The genus Streptobacillus (S.) remained monotypic for almost 90 years until two new species were recently described. The type species, S. moniliformis, is one of the two etiological agents of rat bite fever, an under-diagnosed, worldwide occurring zoonosis. In a polyphasic approach field isolates and reference strains of S. moniliformis, S. hongkongensis, S. felis as well as divergent isolates were characterized by comparison of molecular data (n = 29) and from the majority also by their physiological as well as proteomic properties (n = 22). Based on growth-independent physiological profiling using VITEK2-compact, API ZYM and the Micronaut system fastidious growth-related difficulties could be overcome and streptobacilli could definitively be typed despite generally few differences. While differing in their isolation sites and dates, S. moniliformis isolates were found to possess almost identical spectra in matrix-assisted laser desorption ionization-time of flight mass spectrometry and Fourier transform infrared spectroscopy. Spectroscopic methods facilitated differentiation of S. moniliformis, S. hongkongensis and S. felis as well as one divergent isolate. Sequencing of 16S rRNA gene as well as functional genes groEL, recA and gyrB revealed only little intraspecific variability, but generally proved suitable for interspecies discrimination between all three taxa and two groups of divergent isolates.
License of this version: CC BY 4.0 Unported
Document Type: article
Publishing status: publishedVersion
Issue Date: 2015-08-07
Appears in Collections:Naturwissenschaftliche Fakultät

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pos. country downloads
total perc.
1 image of flag of Germany Germany 96 74.42%
2 image of flag of United States United States 5 3.88%
3 image of flag of Russian Federation Russian Federation 3 2.33%
4 image of flag of France France 3 2.33%
5 image of flag of Portugal Portugal 2 1.55%
6 image of flag of Hungary Hungary 2 1.55%
7 image of flag of United Kingdom United Kingdom 2 1.55%
8 image of flag of China China 2 1.55%
9 image of flag of Switzerland Switzerland 2 1.55%
10 image of flag of Brazil Brazil 2 1.55%
    other countries 10 7.75%

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