In vitro evaluation of PCL and P(3HB) as coating materials for selective laser melted porous titanium implants

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Grau, M.; Matena, J.; Teske, M.; Petersen, S.; Aliuos, P. et al.: In vitro evaluation of PCL and P(3HB) as coating materials for selective laser melted porous titanium implants. In: Materials 10 (2017), Nr. 12, 1344. DOI:

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Titanium is widely used as a bone implant material due to its biocompatibility and high resilience. Since its Young's modulus differs from bone tissue, the resulting "stress shielding" could lead to scaffold loosening. However, by using a scaffold-shaped geometry, the Young's modulus can be adjusted. Also, a porous geometry enables vascularisation and bone ingrowth inside the implant itself. Additionally, growth factors can improve these effects. In order to create a deposit and release system for these factors, the titanium scaffolds could be coated with degradable polymers. Therefore, in the present study, synthetic poly-"-caprolactone (PCL) and the biopolymer poly(3-hydroxybutyrate) (P(3HB)) were tested for coating efficiency, cell adhesion, and biocompatibility to find a suitable coating material. The underlying scaffold was created from titanium by Selective Laser Melting (SLM) and coated with PCL or P(3HB) via dip coating. To test the biocompatibility, Live Cell Imaging (LCI) as well as vitality and proliferation assays were performed. In addition, cell adhesion forces were detected via Single Cell Force Spectroscopy, while the coating efficiency was observed using environmental scanning electron microscopy (ESEM) and energy-dispersive X-ray (EDX) analyses. Regarding the coating efficiency, PCL showed higher values in comparison to P(3HB). Vitality assays revealed decent vitality values for both polymers, while values for PCL were significantly lower than those for blank titanium. No significant differences could be observed between PCL and P(3HB) in proliferation and cell adhesion studies. Although LCI observations revealed decreasing values in cell number and populated area over time on both polymer-coated scaffolds, these outcomes could be explained by the possibility of coating diluent residues accumulating in the culture medium. Overall, both polymers fulfill the requirements regarding biocompatibility. Nonetheless, since only PCL coating ensured the maintenance of the porous implant structure, it is preferable to be used as a coating material for creating a deposit and release system for growth factors.
License of this version: CC BY 4.0 Unported
Document Type: Article
Publishing status: publishedVersion
Issue Date: 2017
Appears in Collections:Fakultät für Maschinenbau

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1 image of flag of Germany Germany 159 71.95%
2 image of flag of United States United States 31 14.03%
3 image of flag of China China 9 4.07%
4 image of flag of France France 6 2.71%
5 image of flag of No geo information available No geo information available 4 1.81%
6 image of flag of Russian Federation Russian Federation 4 1.81%
7 image of flag of Vietnam Vietnam 2 0.90%
8 image of flag of Portugal Portugal 1 0.45%
9 image of flag of Korea, Republic of Korea, Republic of 1 0.45%
10 image of flag of Czech Republic Czech Republic 1 0.45%
    other countries 3 1.36%

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