Non-Invasive Online Monitoring of Cell Growth in Disposable Bioreactors with a Planar Coil

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Reinecke, T.; Biechele, P.; Frickhöffer, M.; Scheper, T.; Zimmermann, S.: Non-Invasive Online Monitoring of Cell Growth in Disposable Bioreactors with a Planar Coil. In: Procedia Engineering 168 (2016), S. 582-585. DOI:

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Sum total of downloads: 75

To ensure high quality output of biotechnological processes, relevant process parameters need to be monitored. As bioprocesses are increasingly executed in single use bioreactors, there is an increasing demand for new sensors applicable to these processes. In this work, we present a low-cost sensor system for continuous non-invasive cell growth monitoring, especially for single use bioreactor applications. The system consists of a planar coil connected to a low cost network analyzer. The coil is attached to the outside of the polymer foil of the single use bioreactor and an impedance spectrum is measured. To evaluate the sensor, E. coli cultivations are performed in a modified cultivation setup, which enables measurements through the polymer foil of a Sartorius BIOSTAT® CultiBag RM, and additionally allows sampling of culture medium for optical density reference measurements. The resonance peak of the coil in the impedance spectrum, is observed as measure for the optical density. Regardless of the simple sensor construction, we found a good correlation between optical density and the damping ratio of the resonance peak.
License of this version: CC BY-NC-ND 4.0 Unported
Document Type: article
Publishing status: publishedVersion
Issue Date: 2016
Appears in Collections:Fakultät für Elektrotechnik und Informatik
Naturwissenschaftliche Fakultät

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pos. country downloads
total perc.
1 image of flag of Germany Germany 58 77.33%
2 image of flag of Argentina Argentina 4 5.33%
3 image of flag of United States United States 2 2.67%
4 image of flag of Russian Federation Russian Federation 2 2.67%
5 image of flag of Europe Europe 2 2.67%
6 image of flag of Belgium Belgium 2 2.67%
7 image of flag of Singapore Singapore 1 1.33%
8 image of flag of Sweden Sweden 1 1.33%
9 image of flag of Korea, Republic of Korea, Republic of 1 1.33%
10 image of flag of China China 1 1.33%
    other countries 1 1.33%

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