Aptasensors for small molecule detection

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Walter, J.-G.; Heilkenbrinker, A.; Austerjost, J.; Timur, S.; Stahl, F. et al.: Aptasensors for small molecule detection. In: Zeitschrift für Naturforschung - Section B Journal of Chemical Sciences 67 (2012), Nr. 10, S. 976-986. DOI: https://doi.org/10.5560/ZNB.2012-0147

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To cite the version in the repository, please use this identifier: https://doi.org/10.15488/2379

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Sum total of downloads: 218




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Abstract: 
Aptamers are single-stranded oligonucleotides composed of RNA or DNA that are able to bind their corresponding targets via molecular recognition. Thus, aptamers can be thought of as nucleic acidbased alternatives to antibodies and have attracted attention as receptors in biosensors. Aptamers seem to be ideal biological recognition elements, since they enable the design of intelligent sensors based on their specific properties. Especially the fact that most aptamers undergo conformational changes during the binding of the target and their oligonucleotide nature can be used to rationally design novel sensing strategies. This review focuses on aptasensors for the detection of small molecules. In the first part, aptamers, their generation and their properties are briefly described. In the second part, different design strategies for aptasensors are reviewed, and examples for the detection of small molecules are given. © 2012 Verlag der Zeitschrift fur Naturforschung.
License of this version: CC BY-NC-ND 3.0 Unported
Document Type: article
Publishing status: publishedVersion
Issue Date: 2012
Appears in Collections:Naturwissenschaftliche Fakultät

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pos. country downloads
total perc.
1 image of flag of Germany Germany 139 63.76%
2 image of flag of China China 14 6.42%
3 image of flag of United States United States 13 5.96%
4 image of flag of Hong Kong Hong Kong 7 3.21%
5 image of flag of Korea, Republic of Korea, Republic of 6 2.75%
6 image of flag of Iran, Islamic Republic of Iran, Islamic Republic of 6 2.75%
7 image of flag of India India 6 2.75%
8 image of flag of New Zealand New Zealand 3 1.38%
9 image of flag of Netherlands Netherlands 3 1.38%
10 image of flag of Spain Spain 3 1.38%
    other countries 18 8.26%

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