A novel multiparametric imaging approach to acute myocarditis using T2-mapping and CMR feature tracking

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Baeßler, B.; Treutlein, M.; Schaarschmidt, F.; Stehning, C.; Schnackenburg, B. et al.: A novel multiparametric imaging approach to acute myocarditis using T2-mapping and CMR feature tracking. In: Journal of Cardiovascular Magnetic Resonance 19 (2017), Nr. 1, 71. DOI: https://doi.org/10.1186/s12968-017-0387-x

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Background: The aim of this study was to evaluate the diagnostic potential of a novel cardiovascular magnetic resonance (CMR) based multiparametric imaging approach in suspected myocarditis and to compare it to traditional Lake Louise criteria (LLC). Methods: CMR data from 67 patients with suspected acute myocarditis were retrospectively analyzed. Seventeen age- and gender-matched healthy subjects served as control. T2-mapping data were acquired using a Gradient-Spin-Echo T2-mapping sequence in short-axis orientation. T2-maps were segmented according to the 16-segments AHA-model and segmental T2 values and pixel-standard deviation (SD) were recorded. Afterwards, the parameters maxT2 (the highest segmental T2 value) and madSD (the mean absolute deviation (MAD) of the pixel-SDs) were calculated for each subject. Cine sequences in three long axes and a stack of short-axis views covering the left and right ventricle were analyzed using a dedicated feature tracking algorithm. Results: A multiparametric imaging model containing madSD and LV global circumferential strain (GCSLV) resulted in the highest diagnostic performance in receiver operating curve analyses (area under the curve [AUC] 0.84) when compared to any model containing a single imaging parameter or to LLC (AUC 0.79). Adding late gadolinium enhancement (LGE) to the model resulted in a further increased diagnostic performance (AUC 0.93) and yielded the highest diagnostic sensitivity of 97% and specificity of 77%. Conclusions: A multiparametric CMR imaging model including the novel T2-mapping derived parameter madSD, the feature tracking derived strain parameter GCSLV and LGE yields superior diagnostic sensitivity in suspected acute myocarditis when compared to any imaging parameter alone and to LLC. © 2017 The Author(s).
License of this version: CC BY 4.0 Unported
Document Type: Article
Publishing status: publishedVersion
Issue Date: 2017
Appears in Collections:Naturwissenschaftliche Fakultät

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pos. country downloads
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1 image of flag of Germany Germany 107 50.95%
2 image of flag of Vietnam Vietnam 39 18.57%
3 image of flag of United States United States 31 14.76%
4 image of flag of China China 8 3.81%
5 image of flag of Tunisia Tunisia 4 1.90%
6 image of flag of Netherlands Netherlands 2 0.95%
7 image of flag of Israel Israel 2 0.95%
8 image of flag of Canada Canada 2 0.95%
9 image of flag of Australia Australia 2 0.95%
10 image of flag of Europe Europe 1 0.48%
    other countries 12 5.71%

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