Dacron® vs. PTFE as bypass materials in peripheral vascular surgery - Systematic review and meta-analysis

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Roll, S.; Müller-Nordhorn, J.; Keil, T.; Scholz, H.; Eidt, D. et al.: Dacron® vs. PTFE as bypass materials in peripheral vascular surgery - Systematic review and meta-analysis. In: BMC Surgery 8 (2008), No. 22. DOI: https://doi.org/10.1186/1471-2482-8-22

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Sum total of downloads: 217

Background: In peripheral vascular bypass surgery different synthetic materials are available for bypass grafting. It is unclear which of the two commonly used materials, polytetrafluoroethylene (PTFE) or polyester (Dacron®) grafts, is to be preferred. Thus, the aim of this meta-analysis and systematic review was to compare the effectiveness of these two prosthetic bypass materials (Dacron® and PTFE). Methods: We performed a systematic literature search in MEDLINE, Cochrane-Library – CENTRAL, EMBASE and other databases for relevant publications in English and German published between 1999 and 2008. Only randomized controlled trials were considered for inclusion. We assessed the methodological quality by means of standardized checklists. Primary patency was used as the main endpoint. Random-effect meta-analysis as well as pooling data in life table format was performed to combine study results. Results: Nine randomized controlled trials (RCT) were included. Two trials showed statistically significant differences in primary patency, one favouring Dacron® and one favouring PTFE grafts, while 7 trials did not show statistically significant differences between the two materials. Meta-analysis on the comparison of PTFE vs. Dacron® grafts yielded no differences with regard to primary patency rates (hazard ratio 1.04 (95% confidence interval [0.85;1.28]), no significant heterogeneity (p = 0.32, I2 = 14%)). Similarly, there were no significant differences with regard to secondary patency rates. Conclusion: Systematic evaluation and meta-analysis of randomized controlled trials comparing Dacron® and PTFE as bypass materials for peripheral vascular surgery showed no evidence of an advantage of one synthetic material over the other.
License of this version: CC BY 2.0 Unported
Document Type: Article
Publishing status: publishedVersion
Issue Date: 2008
Appears in Collections:Wirtschaftswissenschaftliche Fakultät

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pos. country downloads
total perc.
1 image of flag of Germany Germany 134 61.75%
2 image of flag of United States United States 33 15.21%
3 image of flag of China China 7 3.23%
4 image of flag of Switzerland Switzerland 5 2.30%
5 image of flag of No geo information available No geo information available 3 1.38%
6 image of flag of Turkey Turkey 3 1.38%
7 image of flag of India India 2 0.92%
8 image of flag of France France 2 0.92%
9 image of flag of Czech Republic Czech Republic 2 0.92%
10 image of flag of Brazil Brazil 2 0.92%
    other countries 24 11.06%

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