Tumor homing and penetrating peptide-conjugated niosomes as multi-drug carriers for tumor-targeted drug delivery

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Ag Seleci, D.; Seleci, M.; Stahl, F.; Scheper, T.: Tumor homing and penetrating peptide-conjugated niosomes as multi-drug carriers for tumor-targeted drug delivery. In: RSC Advances 7 (2017), Nr. 53, S. 33378-33384. DOI: https://doi.org/10.1039/c7ra05071b

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Sum total of downloads: 112

The development of nanoscale drug delivery systems, which can mediate efficient tumor targeting together with high cellular internalization, is crucial for glioma treatment. The combination of therapeutic agents in nanoparticles provides synergistic effects and allows further surface modifications with targeting ligands for specific glioma therapy. To achieve this goal, both doxorubicin and curcumin were encapsulated in polyethylene glycolated niosomes (PEGNIO). The surface of co-drug loaded PEGNIO was modified with tumor homing and penetrating peptide (tLyp-1). Physicochemical properties were determined via dynamic light scattering (DLS) and spectral analysis. Moreover, flow cytometry studies were performed to examine the specific cellular uptake of the tLyp-1 targeted niosomal formulation. In vitro cytotoxicity and inhibition of tumor-like spheroids growth were investigated on human glioblastoma (U87) and human mesenchymal stem cells (hMSC) cells. The results clearly indicated that the strategy by co-administration of doxorubicin and curcumin with tLyp-1 functionalized niosomes could significantly improve anti-glioma treatment.
License of this version: CC BY-NC 3.0
Document Type: article
Publishing status: publishedVersion
Issue Date: 2017
Appears in Collections:Naturwissenschaftliche Fakultät

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pos. country downloads
total perc.
1 image of flag of Germany Germany 84 75.00%
2 image of flag of China China 11 9.82%
3 image of flag of United States United States 3 2.68%
4 image of flag of Pakistan Pakistan 2 1.79%
5 image of flag of Korea, Republic of Korea, Republic of 2 1.79%
6 image of flag of Japan Japan 2 1.79%
7 image of flag of India India 2 1.79%
8 image of flag of No geo information available No geo information available 1 0.89%
9 image of flag of Mexico Mexico 1 0.89%
10 image of flag of Canada Canada 1 0.89%
    other countries 3 2.68%

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