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Wetzel, C.; Jansen-Olliges, L.; Stadler, M.; Surup, F.; Zeilinger, C. et al.: Analysis of SARS-CoV-2 spike RBD binding to ACE2 and its inhibition by fungal cohaerin C using surface enhanced Raman spectroscopy. In: Biomedical Optics Express 14 (2023), Nr. 8, 4097. DOI: https://doi.org/10.1364/boe.495685
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Sum total of downloads: 5
| Abstract: | |
The structure of the SARS-CoV-2 spike RBD and human ACE2 as well as changes in the structure due to binding activities were analysed using surface enhanced Raman spectroscopy. The inhibitor cohaerin C was applied to inhibit the binding between spike RBD and ACE2. Differences and changes in the Raman spectra were determined using deconvolution of the amide bands and principal component analysis. We thus demonstrate a fast and label-free analysis of the protein structures and the differentiation between bound and unbound states. The approach is suitable for sensing and screening and might be relevant to investigate other protein systems as well. | |
| License of this version: | CC BY 4.0 Unported |
| Document Type: | Article |
| Publishing status: | publishedVersion |
| Issue Date: | 2023 |
| Appears in Collections: | Forschungszentren |
distribution of downloads over the selected time period:
downloads by country:
| pos. | country | downloads | ||
|---|---|---|---|---|
| total | perc. | |||
| 1 |  |
Germany | 4 | 80.00% |
| 2 |  |
United States | 1 | 20.00% |
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