Dichloroacetate affects proliferation but not apoptosis in canine mammary cell lines

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Harting, T.P.; Stubbendorff, M.; Hammer, S.C.; Schadzek, P.; Ngezahayo, A. et al.: Dichloroacetate affects proliferation but not apoptosis in canine mammary cell lines. In: PLoS ONE 12 (2017), Nr. 6, E0178744. DOI: https://doi.org/10.1371/journal.pone.0178744

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Targeting mitochondrial energy metabolism is a novel approach in cancer research and can be traced back to the description of the Warburg effect. Dichloroacetate, a controversially discussed subject of many studies in cancer research, is a pyruvate dehydrogenase kinase inhibitor. Dichloroacetate causes metabolic changes in cancerous glycolysis towards oxidative phosphorylation via indirect activation of pyruvate dehydrogenase in mitochondria. Canine mammary cancer is frequently diagnosed but after therapy prognosis still remains poor. In this study, canine mammary carcinoma, adenoma and non-neoplastic mammary gland cell lines were treated using 10 mM Dichloroacetate. The effect on cell number, lactate release and PDH expression and cell respiration was investigated. Further, the effect on apoptosis and several apoptotic proteins, proliferation, and microRNA expression was evaluated. Dichloroacetate was found to reduce cell proliferation without inducing apoptosis in all examined cell lines. © 2017 Harting et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
License of this version: CC BY 4.0 Unported
Document Type: article
Publishing status: publishedVersion
Issue Date: 2017
Appears in Collections:Naturwissenschaftliche Fakultät

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pos. country downloads
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1 image of flag of Germany Germany 153 89.47%
2 image of flag of United States United States 13 7.60%
3 image of flag of Taiwan Taiwan 1 0.58%
4 image of flag of Portugal Portugal 1 0.58%
5 image of flag of India India 1 0.58%
6 image of flag of Hungary Hungary 1 0.58%
7 image of flag of France France 1 0.58%

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