Poly-epsilon-caprolactone Coated and Functionalized Porous Titanium and Magnesium Implants for Enhancing Angiogenesis in Critically Sized Bone Defects

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Roland, Laura; Grau, Michael; Matena, Julia; Teske, Michael; Gieseke, Matthias et al.: Poly-epsilon-caprolactone Coated and Functionalized Porous Titanium and Magnesium Implants for Enhancing Angiogenesis in Critically Sized Bone Defects. In: International Journal of Molecular Sciences 17 (2015), Nr. 1, 1. DOI: https://doi.org/10.3390/ijms17010001

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For healing of critically sized bone defects, biocompatible and angiogenesis supporting implants are favorable. Murine osteoblasts showed equal proliferation behavior on the polymers poly-epsilon-caprolactone (PCL) and poly-(3-hydroxybutyrate)/poly-(4-hydroxybutyrate) (P(3HB)/P(4HB)). As vitality was significantly better for PCL, it was chosen as a suitable coating material for further experiments. Titanium implants with 600 microm pore size were evaluated and found to be a good implant material for bone, as primary osteoblasts showed a vitality and proliferation onto the implants comparable to well bottom (WB). Pure porous titanium implants and PCL coated porous titanium implants were compared using Live Cell Imaging (LCI) with Green fluorescent protein (GFP)-osteoblasts. Cell count and cell covered area did not differ between the implants after seven days. To improve ingrowth of blood vessels into porous implants, proangiogenic factors like Vascular Endothelial Growth Factor (VEGF) and High Mobility Group Box 1 (HMGB1) were incorporated into PCL coated, porous titanium and magnesium implants. An angiogenesis assay was performed to establish an in vitro method for evaluating the impact of metallic implants on angiogenesis to reduce and refine animal experiments in future. Incorporated concentrations of proangiogenic factors were probably too low, as they did not lead to any effect. Magnesium implants did not yield evaluable results, as they led to pH increase and subsequent cell death.
License of this version: CC BY 4.0 Unported
Document Type: Article
Publishing status: publishedVersion
Issue Date: 2015
Appears in Collections:Fakultät für Maschinenbau

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1 image of flag of Germany Germany 217 72.09%
2 image of flag of United States United States 48 15.95%
3 image of flag of China China 7 2.33%
4 image of flag of Austria Austria 6 1.99%
5 image of flag of No geo information available No geo information available 5 1.66%
6 image of flag of Spain Spain 3 1.00%
7 image of flag of Netherlands Netherlands 2 0.66%
8 image of flag of India India 2 0.66%
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10 image of flag of United Kingdom United Kingdom 1 0.33%
    other countries 9 2.99%

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