Aptamer Microarrays-Current Status and Future Prospects

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Witt, Martin; Walter, Johanna-Gabriela; Stahl, Frank: Aptamer Microarrays-Current Status and Future Prospects. In: Microarrays 4 (2015), Nr. 2, S. 115-132. DOI: https://doi.org/10.3390/microarrays4020115

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Sum total of downloads: 147




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Abstract: 
Microarray technologies are state of the art in biological research, which requires fast genome, proteome and transcriptome analysis technologies. Often antibodies are applied in protein microarrays as proteomic tools. Since the generation of antibodies against toxic targets or small molecules including organic compounds remains challenging the use of antibodies may be limited in this context. In contrast to this, aptamer microarrays provide alternative techniques to circumvent these limitations. In this article we review the latest developments in aptamer microarray technology. We discuss similarities and differences between DNA and aptamer microarrays and shed light on the post synthesis immobilization of aptamers including corresponding effects on the microarray performance. Finally, we highlight current limitations and future prospects of aptamer microarray technology.
License of this version: CC BY 4.0 Unported
Document Type: article
Publishing status: publishedVersion
Issue Date: 2015
Appears in Collections:Naturwissenschaftliche Fakultät

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pos. country downloads
total perc.
1 image of flag of Germany Germany 131 89.12%
2 image of flag of United States United States 4 2.72%
3 image of flag of China China 4 2.72%
4 image of flag of Serbia Serbia 3 2.04%
5 image of flag of Canada Canada 2 1.36%
6 image of flag of Kenya Kenya 1 0.68%
7 image of flag of India India 1 0.68%
8 image of flag of France France 1 0.68%

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