Iron uptake and ferrokinetics in healthy male subjects of an iron-based oral phosphate binder (SBR759) labeled with the stable isotope Fe-58

Downloadstatistik des Dokuments (Auswertung nach COUNTER):

Gschwind, Hans-Peter; Schmid, Dietmar G.; von Blanckenburg, Friedhelm; Oelze, Marcus; van Zuilen, Kirsten; Slade, Alan J.; Stitah, Sylvie; Kaufmann, Daniel; Swart, Piet: Iron uptake and ferrokinetics in healthy male subjects of an iron-based oral phosphate binder (SBR759) labeled with the stable isotope Fe-58. In: Metallomics 6 (2014), Nr. 11, S. 2062-2071. DOI: http://dx.doi.org/10.1039/c4mt00126e

Version im Repositorium

Zum Zitieren der Version im Repositorium verwenden Sie bitte diesen DOI: https://doi.org/10.15488/131

Zeitraum, für den die Download-Zahlen angezeigt werden:

Jahr: 
Monat: 

Summe der Downloads: 271




Kleine Vorschau
Zusammenfassung: 
SBR759 is a novel polynuclear iron(III) oxide–hydroxide starch·sucrose·carbonate complex being developed for oral use in chronic kidney disease (CKD) patients with hyperphosphatemia on hemodialysis. SBR759 binds inorganic phosphate released by food uptake and digestion in the gastro-intestinal tract increasing the fecal excretion of phosphate with concomitant reduction of serum phosphate concentrations. Considering the high content of ∼20% w/w covalently bound iron in SBR759 and expected chronic administration to patients, absorption of small amounts of iron released from the drug substance could result in potential iron overload and toxicity. In a mechanistic iron uptake study, 12 healthy male subjects (receiving comparable low phosphorus-containing meal typical for CKD patients: ≤1000 mg phosphate per day) were treated with 12 g (divided in 3 × 4 g) of stable 58Fe isotope-labeled SBR759. The ferrokinetics of [58Fe]SBR759-related total iron was followed in blood (over 3 weeks) and in plasma (over 26 hours) by analyzing with high precision the isotope ratios of the natural iron isotopes 58Fe, 57Fe, 56Fe and 54Fe by multi-collector inductively coupled mass spectrometry (MC-ICP-MS). Three weeks following dosing, the subjects cumulatively absorbed on average 7.8 ± 3.2 mg (3.8–13.9 mg) iron corresponding to 0.30 ± 0.12% (0.15–0.54%) SBR759-related iron which amounts to approx. 5-fold the basal daily iron absorption of 1–2 mg in humans. SBR759 was well-tolerated and there was no serious adverse event and no clinically significant changes in the iron indices hemoglobin, hematocrit, ferritin concentration and transferrin saturation.
Lizenzbestimmungen: CC BY 3.0
Publikationstyp: article
Publikationsstatus: publishedVersion
Erstveröffentlichung: 2014-07-14
Die Publikation erscheint in Sammlung(en):Naturwissenschaftliche Fakultät

Verteilung der Downloads über den gewählten Zeitraum:

Herkunft der Downloads nach Ländern:

Pos. Land Downloads
Anzahl Proz.
1 image of flag of Germany Germany 245 90,41%
2 image of flag of United Kingdom United Kingdom 13 4,80%
3 image of flag of Japan Japan 2 0,74%
4 image of flag of China China 2 0,74%
5 image of flag of Ukraine Ukraine 1 0,37%
6 image of flag of Russian Federation Russian Federation 1 0,37%
7 image of flag of Mexico Mexico 1 0,37%
8 image of flag of Europe Europe 1 0,37%
9 image of flag of Egypt Egypt 1 0,37%
10 image of flag of Belgium Belgium 1 0,37%
    andere 3 1,11%

Weitere Download-Zahlen und Ranglisten:


Hinweis

Zur Erhebung der Downloadstatistiken kommen entsprechend dem „COUNTER Code of Practice for e-Resources“ international anerkannte Regeln und Normen zur Anwendung. COUNTER ist eine internationale Non-Profit-Organisation, in der Bibliotheksverbände, Datenbankanbieter und Verlage gemeinsam an Standards zur Erhebung, Speicherung und Verarbeitung von Nutzungsdaten elektronischer Ressourcen arbeiten, welche so Objektivität und Vergleichbarkeit gewährleisten sollen. Es werden hierbei ausschließlich Zugriffe auf die entsprechenden Volltexte ausgewertet, keine Aufrufe der Website an sich.

Suche im Repositorium


Durchblättern