Pilot-Scale Production of the Natural Colorant Laetiporic Acid, Its Stability and Potential Applications

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Bergmann, P.; Frank, C.; Reinhardt, O.; Takenberg, M.; Werner, A. et al.: Pilot-Scale Production of the Natural Colorant Laetiporic Acid, Its Stability and Potential Applications. In: Fermentation 8 (2022), Nr. 12, 684. DOI: https://doi.org/10.3390/fermentation8120684

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Laetiporus sulphureus, a wood-decaying basidiomycete, produces yellow-orange pigments in fruiting bodies and, as was recently shown, in submerged cultivated mycelia. Out of four strains, the most potent laetiporic acid producer was identified and its yield compared in different media. The complex Moser b medium was replaced by potato dextrose broth, achieving higher yields at a lower cost. Cultivation was then scaled up from shake flask to a 7 L stirred tank bioreactor. Optimization of parameters led to increased product concentrations up to 1 g L−1, the highest yield reported so far. An in situ product recovery strategy with a biphasic system was established, increasing the yield by 19% on the shake flask scale. A crude ethanolic extract of the biomass was examined for color stability and application trials. In contrast to what has been suggested in the past, the pigment showed limited long-term stability to oxygen and light, but was stable under storage in the dark at 4 °C under nitrogen. The orange extract was successfully incorporated into different matrices like foods, cosmetics and textiles. Laetiporic acid can potentially replace petrochemical based synthetic dyes, and can thus support the development of a circular bioeconomy.
License of this version: CC BY 4.0 Unported
Document Type: Article
Publishing status: publishedVersion
Issue Date: 2022
Appears in Collections:Naturwissenschaftliche Fakultät

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1 image of flag of Germany Germany 21 36.84%
2 image of flag of Denmark Denmark 15 26.32%
3 image of flag of United States United States 12 21.05%
4 image of flag of India India 4 7.02%
5 image of flag of Ukraine Ukraine 1 1.75%
6 image of flag of Poland Poland 1 1.75%
7 image of flag of Netherlands Netherlands 1 1.75%
8 image of flag of Malaysia Malaysia 1 1.75%
9 image of flag of Belarus Belarus 1 1.75%

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