The Orphan Crop Crassocephalum crepidioides Accumulates the Pyrrolizidine Alkaloid Jacobine in Response to Nitrogen Starvation

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Schramm, S.; Rozhon, W.; Adedeji-Badmus, A.N.; Liang, Y.; Nayem, S. et al.: The Orphan Crop Crassocephalum crepidioides Accumulates the Pyrrolizidine Alkaloid Jacobine in Response to Nitrogen Starvation. In: Frontiers in Plant Science 12 (2021), 702985. DOI:

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Sum total of downloads: 51

Crassocephalum crepidioides is an African orphan crop that is used as a leafy vegetable and medicinal plant. Although it is of high regional importance in Sub-Saharan Africa, the plant is still mainly collected from the wild and therefore efforts are made to promote its domestication. However, in addition to beneficial properties, there was first evidence that C. crepidioides can accumulate the highly toxic pyrrolizidine alkaloid (PA) jacobine and here it was investigated, how jacobine production is controlled. Using ecotypes from Africa and Asia that were characterized in terms of their PA profiles, it is shown that the tetraploid C. crepidioides forms jacobine, an ability that its diploid close relative Crassocephalum rubens appears to lack. Evidence is provided that nitrogen (N) deficiency strongly increases jacobine in the leaves of C. crepidioides, that this capacity depends more strongly on the shoot than the root system, and that homospermidine synthase (HSS) activity is not rate-limiting for this reaction. A characterization of HSS gene representation and transcription showed that C. crepidioides and C. rubens possess two functional versions, one of which is conserved, that the HSS transcript is mainly present in roots and that its abundance is not controlled by N deficiency. In summary, this work improves our understanding of how environmental cues impact PA biosynthesis in plants and provides a basis for the development of PA-free C. crepidioides cultivars, which will aid its domestication and safe use. © Copyright © 2021 Schramm, Rozhon, Adedeji-Badmus, Liang, Nayem, Winkelmann and Poppenberger.
License of this version: CC BY 4.0 Unported
Document Type: Article
Publishing status: publishedVersion
Issue Date: 2021
Appears in Collections:Naturwissenschaftliche Fakultät

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1 image of flag of Germany Germany 24 47.06%
2 image of flag of United States United States 11 21.57%
3 image of flag of No geo information available No geo information available 4 7.84%
4 image of flag of China China 3 5.88%
5 image of flag of Taiwan Taiwan 2 3.92%
6 image of flag of Qatar Qatar 1 1.96%
7 image of flag of Jordan Jordan 1 1.96%
8 image of flag of Iran, Islamic Republic of Iran, Islamic Republic of 1 1.96%
9 image of flag of United Kingdom United Kingdom 1 1.96%
10 image of flag of Czech Republic Czech Republic 1 1.96%
    other countries 2 3.92%

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