Contemporary science is marked by expanding and diverse forms of teamwork. Collaboration across organizational and cultural boundaries extends the possibilities of discovery. International collaborative research projects often provide findings beyond what one team could achieve alone. Motivated to maintain existing relationships and grow their scientific network, researchers increasingly collaborate, despite often unrecognized or underappreciated costs, since such projects are challenging to manage and carry out. Rarely studied in-depth and longitudinally, the perspectives of scientific team members are crucial to better understand the dynamics of durable collaboration networks. Thus, this retrospective case study of a sociology of science project applies the novel method of autoethnography to examine teamwork benefits, motivations, and challenges. Key challenges found include spatial distance and differences of culture, language, and career stage. This study, spanning North America, Europe, the Middle East, and East Asia, focused on collaborators' characteristics and evolving perceptions of team dynamics over a decade. © The Author(s) 2021. Published by Oxford University Press.