3D printing in biotechnology—An insight into miniaturized and microfluidic systems for applications from cell culture to bioanalytics

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Heuer, C.; Preuß, J.-A.; Habib, T.; Enders, A.; Bahnemann, J.: 3D printing in biotechnology—An insight into miniaturized and microfluidic systems for applications from cell culture to bioanalytics. In: Engineering in life sciences 22 (2022), Nr. 12, S. 744-759. DOI: https://doi.org/10.1002/elsc.202100081

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Sum total of downloads: 85

Since its invention in the 1980s, 3D printing has evolved into a versatile technique for the additive manufacturing of diverse objects and tools, using various materials. The relative flexibility, straightforwardness, and ability to enable rapid prototyping are tremendous advantages offered by this technique compared to conventional methods for miniaturized and microfluidic systems fabrication (such as soft lithography). The development of 3D printers exhibiting high printer resolution has enabled the fabrication of accurate miniaturized and microfluidic systems—which have, in turn, substantially reduced both device sizes and required sample volumes. Moreover, the continuing development of translucent, heat resistant, and biocompatible materials will make 3D printing more and more useful for applications in biotechnology in the coming years. Today, a wide variety of 3D-printed objects in biotechnology—ranging from miniaturized cultivation chambers to microfluidic lab-on-a-chip devices for diagnostics—are already being deployed in labs across the world. This review explains the 3D printing technologies that are currently used to fabricate such miniaturized microfluidic devices, and also seeks to offer some insight into recent developments demonstrating the use of these tools for biotechnological applications such as cell culture, separation techniques, and biosensors.
License of this version: CC BY-NC 4.0 Unported
Document Type: Article
Publishing status: publishedVersion
Issue Date: 2021
Appears in Collections:Naturwissenschaftliche Fakultät

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pos. country downloads
total perc.
1 image of flag of Germany Germany 57 67.06%
2 image of flag of United States United States 19 22.35%
3 image of flag of China China 5 5.88%
4 image of flag of Iran, Islamic Republic of Iran, Islamic Republic of 3 3.53%
5 image of flag of Taiwan Taiwan 1 1.18%

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