Considerations about the effectiveness and cost effectiveness of therapies in the treatment of hyperphosphataemia

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Plagemann, T.; Prenzler, Anne; Mittendorf, T.: Considerations about the effectiveness and cost effectiveness of therapies in the treatment of hyperphosphataemia. In: Health Economics Review 1 (2011), Nr. 1, S. 1-9. DOI:

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Sum total of downloads: 177

Because of an elevated serum phosphate level, patients who suffer from chronic kidney failure frequently tend to have cardiovascular calcification and are therefore exposed to a higher probability of a fatal event. Phosphate binders are able to reduce these negative effects. Currently, there are primarily two groups of phosphate binders (calcium-containing and calcium-free phosphate binders) which are considered to be almost equally effective in terms of binding of free phosphate. There are, however, a few disadvantages of the two groups. While the calcium-containing binders are associated with an increased risk of hypercalcaemia, which is dose dependent, calcium-free binders have been criticized as being too expensive. As the expenditure for patients suffering from chronic kidney failure increases from year to year, as a result of increasing prevalence, there is a growing need for an alternative to existing phosphate binders. The study presented here therefore summarizes available information for the novel combination preparation OsvaRen® (calcium acetate/magnesium carbonate) as an alternative therapy to the calcium-free phosphate binder Renagel® (sevelamer-hydrochloride) and to calcium-containing preparations. The results of this systematic review showed that OsvaRen® is at least equally effective in the regulation of serum phosphate level as Renagel®. In particular, OsvaRen® shows no clinically relevant difference in terms of the control of the serum calcium levels compared to Renagel® and thereby does not increase the risk of a hypercalcaemia, in contrast to pure calcium-based phosphate binders. On the other hand, Renagel® therapy is much more frequently associated with gastrointestinal side-effects, a tendency to result in higher tablet burden for patients and high medication costs. The CALMAG study showed that OsvaRen® was at least as effective and safe in terms of controlling serum phosphate and serum calcium levels as Renagel® while, at the same time, resulting in about 80% lower costs. In addition, OsvaRen® offers a lower risk of hypercalcaemia and associated subsequent costs and is thereby also superior to pure calcium-containing phosphate binders. Because of the effectiveness and tolerability of calcium acetate/magnesium carbonate, OsvaRen® offers a clinically suitable and, at the same time, cost-effective therapeutic option in the therapy of hyperphosphataemia.
License of this version: CC BY 2.0 Unported
Document Type: Article
Publishing status: publishedVersion
Issue Date: 2011
Appears in Collections:Wirtschaftswissenschaftliche Fakultät

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pos. country downloads
total perc.
1 image of flag of Germany Germany 116 65.54%
2 image of flag of United States United States 20 11.30%
3 image of flag of China China 11 6.21%
4 image of flag of United Kingdom United Kingdom 5 2.82%
5 image of flag of Cyprus Cyprus 5 2.82%
6 image of flag of Thailand Thailand 2 1.13%
7 image of flag of Russian Federation Russian Federation 2 1.13%
8 image of flag of India India 2 1.13%
9 image of flag of Czech Republic Czech Republic 1 0.56%
10 image of flag of Canada Canada 1 0.56%
    other countries 12 6.78%

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