In vitro studies of maleidride-forming enzymes

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Yin, S.; Friedrich, S.; Hrupinsa, V.; Cox, R.J.: In vitro studies of maleidride-forming enzymes. In: RSC Advances 11 (2021), Nr. 25, S. 14922-14931. DOI:

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Sum total of downloads: 45

In vitro assays of enzymes involved in the biosynthesis of maleidrides from polyketides in fungi were performed. The results show that the enzymes are closely related to primary metabolism enzymes of the citric acid cycle in terms of stereochemical preferences, but with an expanded substrate selectivity. A key citrate synthase can react both saturated and unsaturated acyl CoA substrates to give solely anti substituted citrates. This undergoes anti-dehydration to afford an unsaturated precursor which is cyclised in vitro by ketosteroid-isomerase-like enzymes to give byssochlamic acid.
License of this version: CC BY-NC 3.0 Unported
Document Type: Article
Publishing status: publishedVersion
Issue Date: 2021
Appears in Collections:Forschungszentren

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2 image of flag of United States United States 13 28.89%
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4 image of flag of No geo information available No geo information available 1 2.22%
5 image of flag of Taiwan Taiwan 1 2.22%
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