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Haindl, S.; Stark, J.; Dippel, J.; Handt, S.; Reiche, A.: Scale-up of Microfiltration Processes. In: Chemie-Ingenieur-Technik 92 (2020), Nr. 6, S. 746-758. DOI: https://doi.org/10.1002/cite.201900025
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Sum total of downloads: 253
| Abstract: | |
A flow rate and resistance-based approach for upscaling of microfiltration processes from lab scale to process scale is presented, in correlation with biopharmaceutical processes. Basic element is the modeling of filtration curves using a resistance-in-series model based on the Darcy equation. The influences of the filtration setup and the fouling layer are described as additional resistances that change in course of filtration. The necessary parameters, such as setup resistances and filtration areas, are determined by water flow rate measurements. The model is validated by filtration of a particulate test solution. The presented approach can be used for constant flow and constant pressure driven filtration processes. © 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | |
| License of this version: | CC BY 4.0 Unported |
| Document Type: | Article |
| Publishing status: | publishedVersion |
| Issue Date: | 2020 |
| Appears in Collections: | Naturwissenschaftliche Fakultät |
distribution of downloads over the selected time period:
downloads by country:
| pos. | country | downloads | ||
|---|---|---|---|---|
| total | perc. | |||
| 1 |  |
Germany | 119 | 47.04% |
| 2 |  |
United States | 40 | 15.81% |
| 3 |  |
Russian Federation | 12 | 4.74% |
| 4 |  |
United Kingdom | 8 | 3.16% |
| 5 |  |
China | 8 | 3.16% |
| 6 |  |
Turkey | 5 | 1.98% |
| 7 |  |
Czech Republic | 5 | 1.98% |
| 8 |  |
Mexico | 4 | 1.58% |
| 9 |  |
Israel | 4 | 1.58% |
| 10 |  |
Indonesia | 4 | 1.58% |
| other countries | 44 | 17.39% | ||
Further download figures and rankings:
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