Complex systems-such as gas turbines, industrial plants, and infrastructure networks- are of paramount importance to modern societies. However, these systems are subject to various threats. Novel research does not only focus on monitoring and improving the robustness and reliability of systems but also focus on their recovery from adverse events. The concept of resilience encompasses these developments. Appropriate quantitative measures of resilience can support decision-makers seeking to improve or to design complex systems. In this paper, we develop comprehensive and widely adaptable instruments for resilience-based decision-making. Integrating an appropriate resilience metric together with a suitable systemic risk measure, we design numerically efficient tools aiding decision-makers in balancing different resilience-enhancing investments. The approach allows for a direct comparison between failure prevention arrangements and recovery improvement procedures, leading to optimal tradeoffs with respect to the resilience of a system. In addition, the method is capable of dealing with the monetary aspects involved in the decision-making process. Finally, a grid search algorithm for systemic risk measures significantly reduces the computational effort. In order to demonstrate its wide applicability, the suggested decision-making procedure is applied to a functional model of a multistage axial compressor, and to the U-Bahn and S-Bahn system of Germany's capital Berlin. Copyright © 2020 by ASME.