Surgery with fs-laser in the posterior part of the eye could be useful for separation of tractional epiretinal membrane and vitreous floaters treatment. However, focus degradation occurs near the retina due to induced aberrations by cornea and lens. To overcome this issue, adaptive optics with wavefront sensor and wavefront modulator can be utilized. We demonstrate an alternative concept for image guided femto second laser (fs-laser) surgery in the posterior eye with wavefront sensorless adaptive optics (WFSLAO). Our laboratory setup consists of an 800 nm fs-laser and a superluminescent diode (SLD) with 897.2 nm central wavelength. The SLD is used for optical coherence tomography (OCT) whereby the light for the OCT sample arm and the fs-laser share the same optical path which contains a deformable mirror, scanner and focusing optics. Energy calibrated photodiodes are used to measure the threshold energy for a laser induced optical breakdown inside a water filled chamber that acts as simple eye model. OCT image based metrics were used to determine a set of Zernike polynomials that describe a near optimal deformable mirror state. Such a mirror state improved OCT resolution and at the same time lowered the required fs-laser energy for a laser induced optical breakdown inside the eye model substantially. © COPYRIGHT SPIE.