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Browsing by Subject "protein degradation"

Now showing items 1-9 of 9

Early manganese-toxicity response in Vigna unguiculata L. - A proteomic and transcriptomic study

Führs, Hendrik; Hartwig, Moritz; Molina, Laura Elisa Buitrago; Heintz, Dimitri; Van Dorsselaer, Alain; Braun, Hans-Peter; Horst, Walter J. (Weinheim : Wiley VCH, 2008)

The apoplast is known to play a predominant role in the expression of manganese (Mn) toxicity in cowpea (Vigna unguiculata L.) leaves. To unravel early Mn-toxicity responses after 1-3 days Mn treatment also in the leaf ...
Fate of the UPR marker protein Kar2/Bip and autophagic processes in fed-batch cultures of secretory insulin precursor producing Pichia pastoris

Roth, Gustavo; Vanz, Ana Leticia; Lünsdorf, Heinrich; Nimtz, Manfred; Rinas, Ursula (London : BioMed Central Ltd., 2018)

Background: Secretory recombinant protein production with Pichia (syn. Komagataella) pastoris is commonly associated with the induction of an unfolded protein response (UPR) usually apparent through increased intracellular ...
Flow rate dependent continuous hydrolysis of protein isolates

Sewczyk, Tim; Hoog Antink, Marieke; Maas, Michael; Kroll, Stephen; Beutel, Sascha (Heidelberg : Springer Verlag, 2018)

Food protein hydrolysates are often produced in unspecific industrial batch processes. The hydrolysates composition underlies process-related fluctuations and therefore the obtained peptide fingerprint and bioactive ...
The metabolic potential of Escherichia coli BL21 in defined and rich medium

Li, Zhaopeng; Nimtz, Manfred; Rinas, Ursula (London : BioMed Central Ltd., 2014)

Background: The proteome reflects the available cellular machinery to deal with nutrients and environmental challenges. The most common E. coli strain BL21 growing in different, commonly employed media was evaluated using ...
Packaging protein drugs as bacterial inclusion bodies for therapeutic applications

Villaverde, Antonio; García-Fruitós, Elena; Rinas, Ursula; Seras-Franzoso, Joaquin; Kosoy, Ana; Corchero, Josè Luis; Vázquez, Esther (London : BioMed Central Ltd., 2012)

A growing number of insights on the biology of bacterial inclusion bodies (IBs) have revealed intriguing utilities of these protein particles. Since they combine mechanical stability and protein functionality, IBs have ...
Physiological response of Pichia pastoris GS115 to methanol-induced high level production of the Hepatitis B surface antigen: Catabolic adaptation, stress responses, and autophagic processes

Vanz, Ana Leticia; Lünsdorf, Heinrich; Adnan, Ahmad; Nimtz, Manfred; Gurramkonda, Chandrasekhar; Khanna, Navin; Rinas, Ursula (London : BioMed Central Ltd., 2012)

Background: Pichia pastoris is an established eukaryotic host for the production of recombinant proteins. Most often, protein production is under the control of the strong methanol-inducible aox1 promoter. However, detailed ...
Regulatory coiled-coil domains promote head-to-head assemblies of AAA+ chaperones essential for tunable activity control

Carroni, Marta; Franke, Kamila B.; Maurer, Michael; Jäger, Jasmin; Hantke, Ingo; Gloge, Felix; Linder, Daniela; Gremer, Sebastian; Turgay, Kürsad; Bukau, Bernd; Mogk, Axel (Cambridge : eLife Sciences Publications, 2017)

Ring-forming AAA+ chaperones exert ATP-fueled substrate unfolding by threading through a central pore. This activity is potentially harmful requiring mechanisms for tight repression and substrate-specific activation. The ...
Role of gamma-secretase in human umbilical-cord derived mesenchymal stem cell mediated suppression of NK cell cytotoxicity

Chatterjee, Debanjana; Marquardt, Nicole; Tufa, Dejene Milkessa; Beauclair, Guillaume; Low, Hui Zhi; Hatlapatka, Tim; Hass, Ralf; Kasper, Cornelia; Kaisenberg, Constantin von; Schmidt, Reinhold Ernst; Jacobs, Roland (London : BioMed Central Ltd., 2014)

Background: Mesenchymal stem cells (MSCs) are increasingly considered to be used as biological immunosuppressants in hematopoietic stem cell transplantation (HSCT). In the early reconstitution phase following HSCT, natural ...
Side effects of chaperone gene co-expression in recombinant protein production

Martínez-Alonso, Monica; García-Fruitós, Elena; Ferrer-Miralles, Neus; Rinas, Ursula; Villaverde, Antonio (London : BioMed Central Ltd., 2010)

Insufficient availability of molecular chaperones is observed as a major bottleneck for proper protein folding in recombinant protein production. Therefore, co-production of selected sets of cell chaperones along with ...

Now showing items 1-9 of 9

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Browsing by Subject "protein degradation"

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