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Antibiotic uptake in Pseudomonas aeruginosa and its consequences on the metabolome

Garcia Rivera, Mariel Anel (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2021)

The permeability barrier of the outer membrane in Gram-negative bacteria possess an inherent defense towards antibiotics and is subject of study using multidisciplinary approaches and cutting-edge techniques. In this study, ...
Bridging the Gap from Enterotypes to Personalized Dietary Recommendations: A Metabolomics Perspective on Microbiome Research

Bartsch, Madeline; Hahn, Andreas; Berkemeyer, Shoma (Basel : MDPI, 2023)

Advances in high-throughput DNA sequencing have propelled research into the human microbiome and its link to metabolic health. We explore microbiome analysis methods, specifically emphasizing metabolomics, how dietary ...
Charakterisierung der CsrA-vermittelten Modulation des bakteriellen Stoffwechsels und seiner Wirkung auf die Pathogenität

Berndt, Volker (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2019)

Pathogene Bakterien sind in der Lage sich verschiedenen Umweltbedingungen anzupassen und die Immunantwort des Wirts zu umgehen. Diese Fähigkeit erfordert eine schnelle Anpassung der Genexpression, Translation und des ...
Comparative flavonoid profile of orange (Citrus sinensis) flavedo and albedo extracted by conventional and emerging techniques using UPLC-IMS-MS, chemometrics and antioxidant effects

Afifi, Sherif M.; Gök, Recep; Eikenberg, Ingo; Krygier, Dennis; Rottmann, Eric; Stübler, Anne-Sophie; Aganovic, Kemal; Hillebrand, Silke; Esatbeyoglu, Tuba (Lausanne : Frontiers Media, 2023)

Introduction: Citrus fruits are one of the most frequently counterfeited processed products in the world. In the juice production alone, the peels, divided into flavedo and albedo, are the main waste product. The extracts ...
Comparative Metabolite Fingerprinting of Four Different Cinnamon Species Analyzed via UPLC–MS and GC–MS and Chemometric Tools

Farag, Mohamed A.; Kabbash, Eman M.; Mediani, Ahmed; Döll, Stefanie; Esatbeyoglu, Tuba; Afifi, Sherif M. (Basel : MDPI, 2022)

The present study aimed to assess metabolites heterogeneity among four major Cinnamomum species, including true cinnamon (Cinnamomum verum) and less explored species (C. cassia, C. iners, and C. tamala). UPLC-MS led to the ...
Comparative Untargeted Metabolic Profiling of Different Parts of Citrus sinensis Fruits via Liquid Chromatography–Mass Spectrometry Coupled with Multivariate Data Analyses to Unravel Authenticity

Afifi, Sherif M.; Kabbash, Eman M.; Berger, Ralf G.; Krings, Ulrich; Esatbeyoglu, Tuba (Basel : MDPI, 2023)

Differences between seven authentic samples of Citrus sinensis var. Valencia peel (albedo and flavedo) and juices from Spain and Uruguay, in addition to a concentrate obtained from Brazil, were investigated by untargeted ...
Functional associations between the metabolome and manganese tolerance in Vigna unguiculata

Führs, Hendrik; Specht, André; Erban, Alexander; Kopka, Joachim; Horst, Walter J. (Oxford : Oxford University Press, 2012)

Genotypic-and silicon (Si)-mediated differences in manganese (Mn) tolerance of cowpea (Vigna unguiculata) arise from a combination of symplastic and apoplastic traits. A detailed metabolomic inspection could help to identify ...
Metabolome-based studies of virulence factors in Pseudomonas aeruginosa

Depke, Tobias (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2021)

Pseudomonas aeruginosa is an opportunistic pathogen and an important causative agent of potentially life-threatening nosocomial infections in predisposed patients. The Gram-negative bacterium produces a large and diverse ...
Molecular Signatures of the Eagle Effect Induced by the Artificial Siderophore Conjugate LP-600 in E. coli

Lai, Yi-Hui; Franke, Raimo; Pinkert, Lukas; Overwin, Heike; Brönstrup, Mark (Washington, DC : ACS Publ., 2022)

Achieving cellular uptake is a central challenge for novel antibiotics targeting Gram-negative bacterial pathogens. One strategy is to hijack the bacterial iron transport system by siderophore-antibiotic conjugates that ...
The uptake mechanism of synthetic siderophore conjugate in Gram-negative bacteria

Lai, Yi-Hui (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2021)

Drug resistance in bacteria becomes a serious challenge in the clinic, so it is exigent to seek novel and effective antibiotic treatment options. By hijacking the siderophore transport system, siderophore-antibiotic ...

Now showing items 1-10 of 10

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