Auflistung nach Schlagwort "human cell"

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  • Adhesion, Vitality and Osteogenic Differentiation Capacity of Adipose Derived Stem Cells Seeded on Nitinol Nanoparticle Coatings 
    Strauß, Sarah; Neumeister, Anne; Barcikowski, Stephan; Kracht, Dietmar; Kuhbier, Jörn W.; Radtke, Christine; Reimers, Kerstin; Vogt, Peter M. (San Francisco, California, US : PLOS, 2013)
    Autologous cells can be used for a bioactivation of osteoimplants to enhance osseointegration. In this regard, adipose derived stem cells (ASCs) offer interesting perspectives in implantology because they are fast and easy ...
  • Aptamer-modified polymer nanoparticles for targeted drug delivery 
    Modrejewski, Julia; Walter, Johanna-Gabriela; Kretschmer, Imme; Kemal, Evren; Green, Mark; Belhadj, Hamza; Blume, Cornelia; Scheper, Thomas (Berlin : De Gruyter, 2016)
    The purpose of this study was to develop a model system for targeted drug delivery. This system should enable targeted drug release at a certain tissue in the body. In conventional drug delivery systems, drugs are often ...
  • Biofunctional quantum dots as fluorescence probe for cell-specific targeting 
    Ag, Didem; Bongartz, Rebecca; Dogan, Leyla Eral; Seleci, Muharrem; Walter, Johanna-Gabriela; Demirkol, Dilek Odaci; Stahl, Frank; Ozcelik, Serdar; Timur, Suna; Scheper, Thomas (Amsterdam : Elsevier, 2014)
    We describe here the synthesis, characterization, bioconjugation, and application of water-soluble thioglycolic acid TGA-capped CdTe/CdS quantum dots (TGA-QDs) for targeted cellular imaging. Anti-human epidermal growth ...
  • Cancer cell-selective, clathrin-mediated endocytosis of aptamer decorated nanoparticles 
    Engelberg, Shira; Modrejewski, Julia; Walter, Johanna-Gabriela; Livney, Yoav D.; Assaraf, Yehuda G. (S.l. : Impact Journals LLC, 2018)
    Lung cancer is the leading cause of cancer mortality worldwide, resulting in 88% deaths of all diagnosed patients. Hence, novel therapeutic modalities are urgently needed. Single-stranded oligonucleotide-based aptamers ...
  • Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism 
    Hartleben, Goetz; Schorpp, Kenji; Kwon, Yun; Betz, Barbara; Tsokanos, Foivos-Filippos; Dantes, Zahra; Schäfer, Arlett; Rothenaigner, Ina; Monroy Kuhn, José Manuel; Morigny, Pauline; Mehr, Lisa; Lin, Sean; Seitz, Susanne; Tokarz, Janina; Artati, Anna; Adamsky, Jerzy; Plettenburg, Oliver; Lutter, Dominik; Irmler, Martin; Beckers, Johannes; Reichert, Maximilian; Hadian, Kamyar; Zeigerer, Anja; Herzig, Stephan; Berriel Diaz, Mauricio (Weinheim : Wiley-VCH, 2021)
    By accentuating drug efficacy and impeding resistance mechanisms, combinatorial, multi-agent therapies have emerged as key approaches in the treatment of complex diseases, most notably cancer. Using high-throughput drug ...
  • EBIO Does Not Induce Cardiomyogenesis in Human Pluripotent Stem Cells but Modulates Cardiac Subtype Enrichment by Lineage-Selective Survival 
    Jara-Avaca, Monica; Kempf, Henning; Rückert, Michael; Robles-Diaz, Diana; Franke, Annika; de la Roche, Jeanne; Fischer, Martin; Malan, Daniela; Sasse, Philipp; Solodenko, Wladimir; Dräger, Gerald; Kirschning, Andreas; Martin, Ulrich; Zweigerdt, Robert (New York, NY : Springer, 2017)
    Subtype-specific human cardiomyocytes (CMs) are valuable for basic and applied research. Induction of cardiomyogenesis and enrichment of nodal-like CMs was described for mouse pluripotent stem cells (mPSCs) in response to ...
  • Evaluation of the biological tolerability of the starch-based medical device 4DryField® PH in vitro and in vivo a rat model 
    Poehnert, Daniel; Abbas, Mahmoud; Maegel, Lavinia; Sambale, Franziska; Lavrentieva, Antonina; Kreipe, Hans-Heinrich; Klempnauer, Jürgen; Winny, Markus (London : SAGE Publications Ltd., 2015)
    Purpose To evaluate in vitro cytotoxicity/biocompatibility as well as in vivo tolerability of the novel polysaccharide 4DryField® PH, certified for haemostasis and adhesion prevention. Methods In vitro cytotoxicity/viability ...
  • First-in-class positron emission tomography tracer for the glucagon receptor 
    Velikyan, Irina; Haack, Torsten; Bossart, Martin; Evers, Andreas; Laitinen, Ilina; Larsen, Philip; Plettenburg, Oliver; Johansson, Lars; Pierrou, Stefan; Wagner, Michael; Eriksson, Olof (Heidelberg : Springer Verlag, 2019)
    Abstract: The glucagon receptor (GCGR) is emerging as an important target in anti-diabetic therapy, especially as part of the pharmacology of dual glucagon-like peptide-1/glucagon (GLP-1/GCG) receptor agonists. However, ...
  • Human embryonic stem cell-derived test systems for developmental neurotoxicity: A transcriptomics approach 
    Krug, Anne K.; Kolde, Raivo; Gaspar, John A.; Rempel, Eugen; Balmer, Nina V.; Meganathan, Kesavan; Vojnits, Kinga; Baquié, Mathurin; Waldmann, Tanja; Ensenat-Waser, Roberto; Jagtap, Smita; Evans, Richard M.; Julien, Stephanie; Peterson, Hedi; Zagoura, Dimitra; Kadereit, Suzanne; Gerhard, Daniel; Sotiriadou, Isaia; Heke, Michael; Natarajan, Karthick; Henry, Margit; Winkler, Johannes; Marchan, Rosemarie; Stoppini, Luc; Bosgra, Sieto; Westerhout, Joost; Verwei, Miriam; Vilo, Jaak; Kortenkamp, Andreas; Hescheler, Jürgen; Hothorn, Ludwig A.; Bremer, Susanne; van Thriel, Christoph; Krause, Karl-Heinz; Hengstler, Jan G.; Rahnenführer, Jörg; Leist, Marcel; Sachinidis, Agapios (Heidelberg : Springer Verlag, 2013)
    Developmental neurotoxicity (DNT) and many forms of reproductive toxicity (RT) often manifest themselves in functional deficits that are not necessarily based on cell death, but rather on minor changes relating to cell ...
  • Human umbilical cord-derived mesenchymal stem cells utilise activin-A to suppress interferon-gamma production by natural killer cells 
    Chatterjee, Debanjana; Marquardt, Nicole; Tufa, Dejene Milkessa; Hatlapatka, Tim; Hass, Ralf; Kasper, Cornelia; Kaisenberg, Constantin von; Schmidt, Reinhold Ernst; Jacobs, Roland (Lausanne : Frontiers Research Foundation, 2014)
    Following allogeneic hematopoietic stem cell transplantation (HSCT), interferon (IFN)-γ levels in the recipient's body can strongly influence the clinical outcome. Human umbilical cord-derived mesenchymal stem cells (UC-MSCs) ...
  • Hydrogel-based microfluidics for vascular tissue engineering 
    Koroleva, Anastasia; Deiwick, Andrea; Nguyen, Alexander; Narayan, Roger; Shpichka, Anastasia; Kufelt, Olga; Kiyan, Roman; Bagratashvili, Victor N.; Timashev, Peter; Scheper, Thomas; Chichkov, Boris (Berlin : De Gruyter, 2016)
    In this work, we have explored 3-D co-culture of vasculogenic cells within a synthetically modified fibrin hydrogel. Fibrinogen was covalently linked with PEG-NHS in order to improve its degradability resistance and ...
  • Induction of Osteogenic Differentiation of Adipose Derived Stem Cells by Microstructured Nitinol Actuator-Mediated Mechanical Stress 
    Strauß, Sarah; Dudziak, Sonja; Hagemann, Ronny; Barcikowski, Stephan; Fliess, Malte; Israelowitz, Meir; Kracht, Dietmar; Kuhbier, Jörn W.; Radtke, Christine; Reimers, Kerstin; Vogt, Peter M. (San Francisco, California, US : PLOS, 2012)
    The development of large tissue engineered bone remains a challenge in vitro, therefore the use of hybrid-implants might offer a bridge between tissue engineering and dense metal or ceramic implants. Especially the combination ...
  • Murine and human pluripotent stem cell-derived cardiac bodies form contractile myocardial tissue in vitro 
    Kensah, George; Lara, Angelica Roa; Dahlmann, Julia; Zweigerdt, Robert; Schwanke, Kristin; Hegermann, Jan; Skvorc, David; Gawol, Anke; Azizian, Azadeh; Wagner, Stefan; Maier, Lars S.; Krause, Andreas; Dräger, Gerald; Ochs, Matthias; Haverich, Axel; Gruh, Ina; Martin, Ulrich (Oxford : Oxford University Press, 2013)
    AimsWe explored the use of highly purified murine and human pluripotent stem cell (PSC)-derived cardiomyocytes (CMs) to generate functional bioartificial cardiac tissue (BCT) and investigated the role of fibroblasts, ...
  • Novel formulations of c-peptide with long-acting therapeutic potential for treatment of diabetic complications 
    Zashikhina, Natalia; Sharoyko, Vladimir; Antipchik, Mariia; Tarasenko, Irina; Anufrikov, Yurii; Lavrentieva, Antonina; Tennikova, Tatiana; Korzhikova-Vlakh, Evgenia (Basel : MDPI AG, 2019)
    The development and application of novel nanospheres based on cationic and anionic random amphiphilic polypeptides with prolonged stability were proposed. The random copolymers, e.g., poly(L-lysine-co-D-phenylalanine) ...
  • Osteogenic differentiation of human mesenchymal stem cells in 3-D Zr-Si organic-inorganic scaffolds produced by two-photon polymerization technique 
    Koroleva, Anastasia; Deiwick, Andrea; Nguyen, Alexander; Schlie-Wolter, Sabrina; Narayan, Roger; Timashev, Peter; Popov, Vladimir; Bagratashvili, Victor N.; Chichkov, Boris (San Francisco, CA : Public Library of Science, 2015)
    Two-photon polymerization (2PP) is applied for the fabrication of 3-D Zr-Si scaffolds for bone tissue engineering. Zr-Si scaffolds with 150, 200, and 250 μm pore sizes are seeded with human bone marrow stem cells (hBMSCs) ...
  • Precursor B-ALL cell lines differentially respond to syk inhibition by entospletinib 
    Sender, Sina; Sekora, Anett; Perez, Simon V.; Chabanovska, Oleksandra; Becker, Annegret; Ngezahayo, Anaclet; Junghanss, Christian; Murua Escobar, Hugo (Basel : MDPI, 2021)
    Background: Impaired B-cell receptor (BCR) function has been associated with the pro-gress of several B-cell malignancies. The spleen tyrosine kinase (SYK) represents a potential therapeutic target in a subset of B-cell ...
  • Pushing the envelope in tissue engineering: Ex vivo production of thick vascularized cardiac extracellular matrix constructs 
    Sarig, Udi; Nguyen, Evelyne Bao-Vi; Wang, Yao; Ting, Sherwin; Bronshtein, Tomer; Sarig, Hadar; Dahan, Nitsan; Gvirtz, Maskit; Reuveny, Shaul; Oh, Steve K.W.; Scheper, Thomas; Boey, Yin Chiang Freddy; Venkatraman, Subbu S.; Machluf, Marcelle (New Rochelle : Mary Ann Liebert Inc., 2015)
    Functional vascularization is a prerequisite for cardiac tissue engineering of constructs with physiological thicknesses. We previously reported the successful preservation of main vascular conduits in isolated thick ...
  • Role of gamma-secretase in human umbilical-cord derived mesenchymal stem cell mediated suppression of NK cell cytotoxicity 
    Chatterjee, Debanjana; Marquardt, Nicole; Tufa, Dejene Milkessa; Beauclair, Guillaume; Low, Hui Zhi; Hatlapatka, Tim; Hass, Ralf; Kasper, Cornelia; Kaisenberg, Constantin von; Schmidt, Reinhold Ernst; Jacobs, Roland (London : BioMed Central Ltd., 2014)
    Background: Mesenchymal stem cells (MSCs) are increasingly considered to be used as biological immunosuppressants in hematopoietic stem cell transplantation (HSCT). In the early reconstitution phase following HSCT, natural ...
  • Transferrin-decorated niosomes with integrated inp/zns quantum dots and magnetic iron oxide nanoparticles: Dual targeting and imaging of glioma 
    Seleci, Didem Ag; Maurer, Viktor; Barlas, Firat Baris; Porsiel, Julian Cedric; Temel, Bilal; Ceylan, Elcin; Timur, Suna; Stahl, Frank; Scheper, Thomas; Garnweitner, Georg (Basel : MDPI, 2021)
    The development of multifunctional nanoscale systems that can mediate efficient tumor targeting, together with high cellular internalization, is crucial for the diagnosis of glioma. The combination of imaging agents into ...
  • Urokinase receptor counteracts vascular smooth muscle cell functional changes induced by surface topography 
    Kiyan, Yulia; Kurselis, Kestutis; Kiyan, Roman; Haller, Hermann; Chichkov, Boris; Dumler, Inna (Wyoming, NSW : Ivyspring, 2013)
    Molecular beacons (MBs) of DCurrent treatments for human coronary artery disease necessitate the development of the next generations of vascular bioimplants. Recent reports provide evidence that controlling cell orientation ...