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Browsing by Subject "gene therapy"

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Advanced therapy medicinal products and health technology assessment principles and practices for value-based and sustainable healthcare

Jönsson, Bengt; Hampson, Grace; Michaels, Jonathan; Towse, Adrian; Schulenburg, Johann-Matthias Graf von der; Wong, Olivier (Heidelberg : Springer Verlag, 2018)

Background: Advanced therapy medicinal products (ATMPs) are beginning to reach European markets, and questions are being asked about their value for patients and how healthcare systems should pay for them. Objectives: To ...
Die Bedeutung von Glucokinase und GLUT2-Glucosetransporter in insulinproduzierenden Zellen für die Regulation der glucoseinduzierten Insulinsekretion und die Toxizität gegenüber diabetogenen Substanzen

Elsner, Matthias (Hannover : Universität Hannover, 2000)

[no abstract]
Die Bedeutung zytoprotektiver Enzyme für den Schutz insulinproduzierender Zellen gegenüber einer Schädigung durch Sauerstoffradikale, NO und Zytokine

Lortz, Stephan (Hannover : Universität, 1999)

[no abstract]
Entwicklung eines Gentherapieansatzes bei Hereditärer Amyloidose durch spezifische Spaltung der Transthyretin-Met30 mRNA mit chemisch modifizierten Inosin 15.1 -Hammerhead-Ribozymen

Pröpsting, Marcus Johannes (Hannover : Universität Hannover, 1999)

[no abstract]
Novel suspension retroviral packaging cells generated by transposition using transposase encoding mRNA advance vector yields and enable production in bioreactors

van Heuvel, Yasemin; Schatz, Stefanie; Hein, Marc; Dogra, Tanya; Kazenmaier, Daniel; Tschorn, Natalie; Genzel, Yvonne; Stitz, Jörn (Lausanne : Frontiers Media, 2023)

To date, the establishment of high-titer stable viral packaging cells (VPCs) at large scale for gene therapeutic applications is very time- and cost-intensive. Here we report the establishment of three human suspension ...
A novel vector for the gene therapy of the Wiskott-Aldrich syndrome

Avedillo Díez, Inés (Hannover : Gottfried Wilhelm Leibniz Universität Hannover, 2010)

[no abstract]
Optimization of retroviral packaging cells for scale-up of vector production

van Heuvel, Yasemin (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2023-09-13)

Retroviral vectors (RVVs) are the key players for somatic gene therapy. However, the large-scale production is very time- and cost-intensive due to the production in adherent cell lines and transient plasmid transfections. ...
Promotor and 5'splice site interactions in retroviruses and retroviral vectors

Zychlinski, Daniela (Hannover : Gottfried Wilhelm Leibniz Universität Hannover, 2009)

[no abstract]
Recommendations for economic evaluations of cell and gene therapies: a systematic literature review with critical appraisal

Toumi, Mondher; Dabbous, Omar; Aballéa, Samuel; Drummond, Michael F.; Schulenburg, Johann-Matthias Graf von der; Malone, Daniel C.; Neumann, Peter J.; Sullivan, Sean D.; Tunis, Sean (Abingdon : Taylor & Francis Group, 2023)

Objective: No consensus exists on the ideal methodology to evaluate the economic impact and value of new, potentially curative gene therapies. We aimed to identify and describe published methodologic recommendations for ...
Retroviral particle-mediated mRNA transfer

Galla, Melanie (Hannover : Gottfried Wilhelm Leibniz Universität Hannover, 2008)

[no abstract]

Now showing items 1-10 of 10

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