Browsing by Subject "geldanamycin"

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New geldanamycin derivatives with anti Hsp properties by mutasynthesis

Hermane, Jekaterina; Eichner, Simone; Mancuso, Lena; Schröder, Benjamin; Sasse, Florenz; Zeilinger, Carsten; Kirschning, Andreas (Cambridge : Royal Society of Chemistry, 2019)

Mutasynthetic supplementation of the AHBA blocked mutant strain of S. hygroscopicus, the geldanamycin producer, with 21 aromatic and heteroaromatic amino acids provided new nonquinoid geldanamycin derivatives. Large scale ...
Studies on ansamycin antibiotics : mutasynthetic approach towards new rifamycin derivatives and total synthesis of progeldanamycin derivatives

Bułyszko, Ilona (Hannover : Gottfried Wilhelm Leibniz Universität Hannover, 2016)

[no abstract]
Targeting heat-shock-protein 90 (Hsp90) by natural products: Geldanamycin, a show case in cancer therapy

Franke, Jana; Eichner, Simone; Zeilinger, Carsten; Kirschning, Andreas (Cambridge : Royal Society of Chemistry, 2013)

Covering: 2005 to 2013 In this review recent progress in the development of heat shock proteins (Hsp90) in oncogenesis is illuminated. Particular emphasis is put on inhibitors such as geldanamycin and analogues that serve ...

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