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Advanced therapy medicinal products and health technology assessment principles and practices for value-based and sustainable healthcare

Jönsson, Bengt; Hampson, Grace; Michaels, Jonathan; Towse, Adrian; Schulenburg, Johann-Matthias Graf von der; Wong, Olivier (Heidelberg : Springer Verlag, 2018)

Background: Advanced therapy medicinal products (ATMPs) are beginning to reach European markets, and questions are being asked about their value for patients and how healthcare systems should pay for them. Objectives: To ...
Decomposing bulk signals to reveal hidden information in processive enzyme reactions: A case study in mRNA translation

Haase, Nadin; Holtkamp, Wolf; Christ, Simon; Heinemann, Dag; Rodnina, Marina V.; Rudorf, Sophia (San Francisco, Calif. : Public Library of Science, 2024)

Processive enzymes like polymerases or ribosomes are often studied in bulk experiments by monitoring time-dependent signals, such as fluorescence time traces. However, due to biomolecular process stochasticity, ensemble ...
Feasibility of Round Window Stimulation by a Novel Electromagnetic Microactuator

Van Drunen, Wouter Johannes; Mueller, Mathias; Glukhovskoy, Anatoly; Salcher, Rolf; Wurz, Marc Christopher; Lenarz, Thomas; Maier, Hannes (New York, NY : Hindawi Publishing Corporation, 2017)

Introduction. Most implantable hearing aids currently available were developed to compensate the sensorineural hearing loss by driving middle ear structures (e.g., the ossicles). These devices are successfully used in round ...
Improving mobility and participation of older people with vertigo, dizziness and balance disorders in primary care using a care pathway: feasibility study and process evaluation

Seckler, Eva; Regauer, Verena; Krüger, Melanie; Gabriel, Anna; Hermsdörfer, Joachim; Niemietz, Carolin; Bauer, Petra; Müller, Martin (London : BioMed Central, 2021)

Background: Community-dwelling older people are frequently affected by vertigo, dizziness and balance disorders (VDB). We previously developed a care pathway (CPW) to improve their mobility and participation by offering ...
On the feasibility of imaging carbonatite-hosted rare earth element deposits using remote sensing

Neave, David A.; Black, Martin; Riley, Teal R.; Gibson, Sally A.; Ferrier, Graham; Wall, Frances; Broom-Fendley, Sam (Littleton, CO : Society of Economic Geologists, Inc, 2016)

Rare earth elements (REEs) generate characteristic absorption features in visible to shortwave infrared (VNIRSWIR) reflectance spectra. Neodymium (Nd) has among the most prominent absorption features of the REEs and thus ...
Optimization of PEG-salt aqueous two-phase systems by design of experiments

Glyk, Anna; Solle, Dörte; Scheper, Thomas; Beutel, Sascha (Amsterdam : Elsevier, 2015)

Since the mechanism governing the partitioning behavior of biomolecules, such as proteins and enzymes, in polyethylene glycol (PEG)-salt aqueous two-phase systems (ATPS) is complex and not easily predictable, many laborious ...
Valuation of the EQ-5D-5L with composite time trade-off for the German population - an exploratory study

Ludwig, Kristina; Schulenburg, Johann-Matthias Graf von der; Greiner, Wolfgang (London : BioMed Central Ltd., 2017)

Background: The EuroQol Group has extended the severity levels of the EQ-5D from three to five (EQ-5D-5L). There are valuation studies worldwide planned in order to convert the EQ-5D-5L health states into a single ...

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