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Auflistung nach Schlagwort "controlled study"

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3D in vitro platform produced by two-photon polymerization for the analysis of neural network formation and function

Timashev, P.S.; Vedunova, M.V.; Guseva, D.; Ponimaskin, E.; Deiwick, A.; Mishchenko, T.A.; Mitroshina, E.V.; Koroleva, A.V.; Pimashkin, A.S.; Mukhina, I.V.; Panchenko, V.Y.; Chichkov, Boris; Bagratashvili, Victor N. (Bristol : Institute of Physics Publishing, 2016)

Zr-Si organic-inorganic scaffolds fabricated by a two-photon polymerization technique were used for the primary culture of mouse embryonic neural cells. We observed that dissociated hippocampal cells adhere to the scaffolds, ...
A novel shape memory plate osteosynthesis for noninvasive modulation of fixation stiffness in a rabbit tibia osteotomy model

Müller, Christian W.; Pfeifer, Ronny; Meier, Karen; Decker, Sebastian; Reifenrath, Janin; Gösling, Thomas; Wesling, Volker; Krettek, Christian; Hurschler, Christof; Krämer, Manuel (New York, NY : Hindawi Publishing Corporation, 2015)

Nickel-titanium shape memory alloy (NiTi-SMA) implants might allow modulating fracture healing, changing their stiffness through alteration of both elastic modulus and cross-sectional shape by employing the shape memory ...
A scalable high-performance magnetic shield for very long baseline atom interferometry

Wodey, E.; Tell, D.; Rasel, E.M.; Schlippert, D.; Baur, R.; Kissling, U.; Kölliker, B.; Lorenz, M.; Marrer, M.; Schläpfer, U.; Widmer, M.; Ufrecht, C.; Stuiber, S.; Fierlinger, P. (College Park, MD : American Institute of Physics, 2020)

We report on the design, construction, and characterization of a 10 m-long high-performance magnetic shield for very long baseline atom interferometry. We achieve residual fields below 4 nT and longitudinal inhomogeneities ...
Adhesion, Vitality and Osteogenic Differentiation Capacity of Adipose Derived Stem Cells Seeded on Nitinol Nanoparticle Coatings

Strauß, Sarah; Neumeister, Anne; Barcikowski, Stephan; Kracht, Dietmar; Kuhbier, Jörn W.; Radtke, Christine; Reimers, Kerstin; Vogt, Peter M. (San Francisco, California, US : PLOS, 2013)

Autologous cells can be used for a bioactivation of osteoimplants to enhance osseointegration. In this regard, adipose derived stem cells (ASCs) offer interesting perspectives in implantology because they are fast and easy ...
AFLP-based genetic mapping of the " bud-flowering" trait in heather (Calluna vulgaris)

Behrend, Anne; Borchert, Thomas; Spiller, Monika; Hohe, Annette (London : BioMed Central Ltd., 2013)

Background: Calluna vulgaris is one of the most important landscaping plants produced in Germany. Its enormous economic success is due to the prolonged flower attractiveness of mutants in flower morphology, the so-called ...
An unusual overrepresentation of genetic factors related to iron homeostasis in the genome of the fluorescent Pseudomonas sp. ABC1

Valenzuela-Heredia, Daniel; Henríquez-Castillo, Carlos; Donoso, Raúl; Lavín, Paris; Ringel, Michael T.; Brüser, Thomas; Campos, José Luis (Oxford : Wiley-Blackwell, 2021)

Members of the genus Pseudomonas inhabit diverse environments, such as soil, water, plants and humans. The variability of habitats is reflected in the diversity of the structure and composition of their genomes. This ...
Aptamer-modified polymer nanoparticles for targeted drug delivery

Modrejewski, Julia; Walter, Johanna-Gabriela; Kretschmer, Imme; Kemal, Evren; Green, Mark; Belhadj, Hamza; Blume, Cornelia; Scheper, Thomas (Berlin : De Gruyter, 2016)

The purpose of this study was to develop a model system for targeted drug delivery. This system should enable targeted drug release at a certain tissue in the body. In conventional drug delivery systems, drugs are often ...
Auditory proprioceptive integration: Effects of real-time kinematic auditory feedback on knee proprioception

Ghai, Shashank; Schmitz, Gerd; Hwang, Tong-Hun; Effenberg, Alfred O. (Lausanne : Frontiers Media S.A., 2018)

The purpose of the study was to assess the influence of real-time auditory feedback on knee proprioception. Thirty healthy participants were randomly allocated to control (n = 15), and experimental group I (15). The ...
Biodegradation of a magnesium alloy implant in the intercondylar femoral notch showed an appropriate response to the synovial membrane in a rabbit model in vivo

Ezechieli, Marco; Diekmann, Julia; Weizbauer, Andreas; Becher, Christoph; Willbold, Elmar; Helmecke, Patrick; Lucas, Arne; Schavan, Robert; Windhagen, Henning (London : SAGE Publications Ltd., 2014)

Degradable magnesium alloys are promising biomaterials for orthopedic applications. The aim of this study was to evaluate the potential effects on both the synovial membrane (synovialis) and the synovial fluid (synovia) ...
Biodistribution, biocompatibility and targeted accumulation of magnetic nanoporous silica nanoparticles as drug carrier in orthopedics

Janßen, Hilke Catherina; Angrisani, Nina; Kalies, Stefan; Hansmann, Florian; Kietzmann, Manfred; Warwas, Dawid Peter; Behrens, Peter; Reifenrath, Janin (London : BioMed Central Ltd., 2020)

Background: In orthopedics, the treatment of implant-associated infections represents a high challenge. Especially, potent antibacterial effects at implant surfaces can only be achieved by the use of high doses of antibiotics, ...
Biofunctional quantum dots as fluorescence probe for cell-specific targeting

Ag, Didem; Bongartz, Rebecca; Dogan, Leyla Eral; Seleci, Muharrem; Walter, Johanna-Gabriela; Demirkol, Dilek Odaci; Stahl, Frank; Ozcelik, Serdar; Timur, Suna; Scheper, Thomas (Amsterdam : Elsevier, 2014)

We describe here the synthesis, characterization, bioconjugation, and application of water-soluble thioglycolic acid TGA-capped CdTe/CdS quantum dots (TGA-QDs) for targeted cellular imaging. Anti-human epidermal growth ...
Biologic TNF inhibiting agents for treatment of inflammatory rheumatic diseases: Dosing patterns and related costs in Switzerland from a payers perspective

Zeidler, Jan; Mittendorf, Thomas; Müller, Rüdiger; Kempis, Johannes von (Heidelberg : Springer Verlag, 2012)

Background: To obtain detailed real-life data on costs and dosing patterns in the utilisation of the TNF inhibitors adalimumab, etanercept, and infliximab in patients treated in Switzerland. Methods: Administrative claims ...
Cancer cell-selective, clathrin-mediated endocytosis of aptamer decorated nanoparticles

Engelberg, Shira; Modrejewski, Julia; Walter, Johanna-Gabriela; Livney, Yoav D.; Assaraf, Yehuda G. (S.l. : Impact Journals LLC, 2018)

Lung cancer is the leading cause of cancer mortality worldwide, resulting in 88% deaths of all diagnosed patients. Hence, novel therapeutic modalities are urgently needed. Single-stranded oligonucleotide-based aptamers ...
Carbonic anhydrase subunits form a matrix-exposed domain attached to the membrane arm of mitochondrial complex I in plants

Sunderhaus, Stephanie; Dudkina, Natalya V.; Jänsch, Lothar; Klodmann, Jennifer; Heinemeyer, Jesco; Perales, Mariano; Zabaleta, Eduardo; Boekema, Egbert J.; Braun, Hans-Peter (Bethesda, Md. : ASBMB Publications, 2006)

Complex I of Arabidopsis includes five structurally related subunits representing γ-type carbonic anhydrases termed CA1, CA2, CA3, CAL1, and CAL2. The position of these subunits within complex I was investigated. Direct ...
Co-transfection of plasmid DNA and laser-generated gold nanoparticles does not disturb the bioactivity of GFP-HMGB1 fusion protein

Petersen, Svea; Soller, Jan T.; Wagner, Siegfried; Richter, Andreas; Bullerdiek, Jörn; Nolte, Ingo; Barcikowski, Stephan; Murua Escobar, Hugo (London : Biomed Central, 2009)

Ultrashort pulsed laser ablation in liquids represents a powerful tool for the generation of pure gold nanoparticles (AuNPs) avoiding chemical precursors and thereby making them especially interesting for biomedical ...
Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism

Hartleben, Goetz; Schorpp, Kenji; Kwon, Yun; Betz, Barbara; Tsokanos, Foivos-Filippos; Dantes, Zahra; Schäfer, Arlett; Rothenaigner, Ina; Monroy Kuhn, José Manuel; Morigny, Pauline; Mehr, Lisa; Lin, Sean; Seitz, Susanne; Tokarz, Janina; Artati, Anna; Adamsky, Jerzy; Plettenburg, Oliver; Lutter, Dominik; Irmler, Martin; Beckers, Johannes; Reichert, Maximilian; Hadian, Kamyar; Zeigerer, Anja; Herzig, Stephan; Berriel Diaz, Mauricio (Weinheim : Wiley-VCH, 2021)

By accentuating drug efficacy and impeding resistance mechanisms, combinatorial, multi-agent therapies have emerged as key approaches in the treatment of complex diseases, most notably cancer. Using high-throughput drug ...
Comparative in vitro study and biomechanical testing of two different magnesium alloys

Weizbauer, Andreas; Modrejewski, Christian; Behrens, Sabine; Klein, Helmut; Helmecke, Patrick; Seitz, Jan-Marten; Windhagen, Henning; Möhwald, Kai; Reifenrath, Janin; Waizy, Hazibullah (London : SAGE Publications Ltd., 2014)

In this in vitro study, magnesium plates of ZEK100 and MgCa0.8 alloy similar to common titanium alloy osteosynthesis plates were investigated as degradable biomedical materials with a focus on primary stability. Immersion ...
Comparison of plasma responses human subjects after the ingestion of 3R,3R′-zeaxanthin dipalmitate from wolfberry (Lycium barbarum) and non-esterified 3R,3R′-zeaxanthin using chiral high-performance liquid chromatography

Breithaupt, Dietmar E.; Weller, Philipp; Wolters, Maike; Hahn, Andreas (Cambridge : Cambridge University Press, 2004)

Age-related macular degeneration (AMD) is one of the most common eye diseases of elderly individuals. It has been suggested that lutein and zeaxanthin may reduce the risk for AMD. Information concerning the absorption of ...
Comparison of two prototypes of a magnetically adjustable glaucoma implant in rabbits

Schwerk, Birthe; Harder, Lisa; Windhövel, Claudia; Hewicker-Trautwein, Marion; Wagner, Anna; Bach, Jan-Peter; Voigt, Lena Carolin; Hinze, Ulf; Chichkov, Boris; Haferkamp, Heinz; Lubatschowski, Holger; Nikolic, Stephan; Nolte, Ingo (San Francisco, CA : Public Library of Science (PLoS), 2019)

Glaucoma drainage devices are used in surgical glaucoma therapy. Success of controlling the intraocular pressure is limited due to fibrous implant encapsulation and fibrin coating on the implant which lead to drainage ...
Continuous optical in-line glucose monitoring and control in CHO cultures contributes to enhanced metabolic efficiency while maintaining darbepoetin alfa product quality

Lederle, Mario; Tric, Mircea; Roth, Tatjana; Schütte, Lina; Rattenholl, Anke; Lütkemeyer, Dirk; Wölfl, Stefan; Werner, Tobias; Wiedemann, Philipp (Weinheim : Wiley-VCH, 2021)

Great efforts are directed towards improving productivity, consistency and quality of biopharmaceutical processes and products. One particular area is the development of new sensors for continuous monitoring of critical ...

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