Browsing by Subject "biosynthesis"

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  • Meinhardt-Wollweber, Merve; Krebs, Ronald (Cambridge : Royal Society of Chemistry, 2012)
    Low levels of vitamin D have been implicated in a wide variety of health issues from calcemic diseases to cancer, diabetes and cardiovascular disease. For most humans, the majority of vitamin D 3 is derived from sunlight. ...
  • Hong, Hui; Samborskyy, Markiyan; Lindner, Frederick; Leadlay, Peter F. (Weinheim : Wiley Online Library, 2016)
    Desertomycin A is an aminopolyol polyketide containing a macrolactone ring. We have proposed that desertomycin A and similar compounds (marginolactones) are formed by polyketide synthases primed not with gamma-aminobutanoyl-CoA ...
  • Yin, Sen (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2020)
    Das Hauptaugenmerk der vorgestellten Arbeit lag auf dem Verständnis des Biosynthesewegs von Viridofungin, der Untersuchung der enzymatischen Eigenschaften der Schlüsselenzyme aus dem Byssochlaminsäure-Weg und der Entwicklung ...
  • Trenti, Francesco (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2018)
    The presented work focuses on the biosynthesis of fungal natural products. Structural analysis of phyllostictine A revealed the literature structure to be erroneous and led to the revised bicyclic 3-methylene tetramic ...
  • Tian, Dongsong (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2021-09-15)
    The project focused on understanding the biosynthesis of sporothriolides, sporochartines and trienylfuranol A. Gene cluster identification, gene knock out, heterologous expression and protein in vitro assays were used ...
  • Schor, Raissa (Hannover : Insititutionelles Repositorium der Leibniz Universität Hannover, 2018)
    Xenovulenes are a family of fungal meroterpenoids produced by the ascomycete Acremonium strictum. Xenovulene A binds the GABA receptor in vitro. The compound exhibits an unusual tetrahydrofuro-cyclopentenone attached to a ...
  • Zhang, Haili; Hantke, Verena; Bruhnke, Pia; Skellam, Elizabeth J.; Cox, Russell J. (Weinheim : Wiley-VCH Verl., 2020)
    A key step during the biosynthesis of cytochalasans is a proposed Knoevenagel condensation to form the pyrrolone core, enabling the subsequent 4+2 cycloaddition reaction that results in the characteristic octahydroisoindolone ...
  • Kahlert, Lukas; Bassiony, Eman F.; Cox, Russell J.; Skellam, Elisabeth J. (Weinheim : Wiley-VCH Verl., 2020)
    The sorbicillinoids are a class of biologically active and structurally diverse fungal polyketides arising from sorbicillin. Through co-expression of sorA, sorB, sorC, and sorD from Trichoderma reesei QM6a, the biosynthetic ...
  • Song, Zhongshu; Bakeer, Walid; Marshall, James W.; Yakasai, Ahmed A.; Khalid, Rozida Mohd; Collemare, Jerome; Skellam, Elizabeth; Tharreau, Didier; Lebrun, Marc-Henri; Lazarus, Colin M.; Bailey, Andrew M.; Simpson, Thomas J.; Cox, Russell J. (Cambridge : Royal Society of Chemistry, 2015-06-01)
    The ACE1 and RAP1 genes from the avirulence signalling gene cluster of the rice blast fungus Magnaporthe oryzae were expressed in Aspergillus oryzae and M. oryzae itself. Expression of ACE1 alone produced a polyenyl pyrone ...
  • Williams, Katherine; Szwalbe, Agnieszka J.; Mulholland, Nicholas P.; Vincent, Jason L.; Bailey, Andrew M.; Willis, Christine L.; Simpson, Thomas J.; Cox, Russell J. (Weinheim : Wiley-VCH Verlag, 2016)
    Fungal maleidrides are an important family of bioactive secondary metabolites that consist of 7, 8, or 9-membered carbocycles with one or two fused maleic anhydride moieties. The biosynthesis of byssochlamic acid (a ...
  • Kandziora, Nadine (Hannover : Gottfried Wilhelm Leibniz Universität Hannover, 2015)
    [no abstract]
  • Li, Lei (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2022)
    The main focus of the presented work concentrated on understanding the biosynthetic pathways of tropolone sesquiterpenoids (TS) and scytolide in fungi. Tropolone sesquiterpenoids, such as pycnidione 22 and eupenifeldin ...
  • Lebe, Karen Elisabeth (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2020)
    The main focus of the presented work concentrated on understanding and engineering the biosynthesis of three polyketides produced by filamentous fungi: squalestatin S1, strobilurin A and SCH–642305. In a combined genetic ...
  • Abood, Amira; Al-Fahad, Ahmed; Scott, Alan; Hosny, Alaa El-Dein M. S.; Hashem, Amal M.; Fattah, Azza M.A.; Race, Paul R.; Simpson, Thomas J.; Cox, Russell J. (Cambridge : Royal Society of Chemistry, 2015-05-29)
    Achieving regio-specific hydroxylation of aromatic compounds remains a major challenge in synthetic chemistry. By contrast, this transformation is readily accomplished in nature through the action of FAD-dependant monooxygenase ...
  • Juerjens, Gerrit; Kirschning, Andreas; Candito, David A. (Cambridge : Royal Society of Chemistry, 2015-03-02)
    This conceptual review examines the ideal multistep synthesis from the perspective of nature. We suggest that besides step- and redox economies, one other key to efficiency is steady state processing with intermediates ...
  • Medema, Marnix H.; Kottmann, Renzo; Yilmaz, Pelin; Cummings, Matthew; Biggins, John B.; Cox, Russell J.; et al. (London : Nature Publishing Group, 2015)
    A wide variety of enzymatic pathways that produce specialized metabolites in bacteria, fungi and plants are known to be encoded in biosynthetic gene clusters. Information about these clusters, pathways and metabolites is ...
  • He, Yi; Cox, Russell J. (Cambridge : Royal Society of Chemistry, 2016)
    The individual steps of citrinin 1 biosynthesis in Monascus ruber M7 were determined by a combination of targeted gene knockout and heterologous gene expression in Aspergillus oryzae. The pathway involves the synthesis of ...
  • Rand, Katrin; Noll, Claudia; Schiebel, Hans Martin; Kemken, Dorit; Dülcks, Thomas; Kalesse, Markus; Heinz, Dirk W.; Layer, Gunhild (Berlin : De Gruyter, 2010)
    During heme biosynthesis the oxygen-independent coproporphyrinogen III oxidase HemN catalyzes the oxidative decarboxylation of the two propionate side chains on rings A and B of coproporphyrinogen III to the corresponding ...
  • Lu, Hai-Hua; Hinkelmann, Bettina; Tautz, Thomas; Li, Jun; Sasse, Florenz; Franke, Raimo; Kalesse, Markus (Cambridge : Royal Society of Chemistry, 2015-06-19)
    The soraphens are natural products that exhibit a molecular structure different from what would have been expected by following its polyketidal assembly line. The most significant differences are the presence of a hemiketal ...
  • Brazhe, Nadezda A.; Evlyukhin, Andrey B.; Goodilin, Eugene A.; Semenova, Anna A.; Novikov, Sergey M.; Bozhevolnyi, Sergey I.; Chichkov, Boris; Sarycheva, Asya S.; Baizhumanov, Adil A.; Nikelshparg, Evelina I.; Deev, Leonid I.; Maksimov, Eugene G.; Maksimov, Georgy V.; Sosnovtseva, Olga (London : Nature Publishing Group, 2015)
    Selective study of the electron transport chain components in living mitochondria is essential for fundamental biophysical research and for the development of new medical diagnostic methods. However, many important details ...