Browsing by Subject "aptamer"

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  • Arshavsky-Graham, Sofia; Enders, Anton; Ackerman, Shanny; Bahnemann, Janina; Segal, Ester (Wien [u.a.] : Springer, 2021)
    Microfluidic integration of biosensors enables improved biosensing performance and sophisticated lab-on-a-chip platform design for numerous applications. While soft lithography and polydimethylsiloxane (PDMS)-based ...
  • Seiler, Lisa K.; Phung, Ngoc Linh; Nikolin, Christoph; Immenschuh, Stephan; Erck, Christian; Kaufeld, Jessica; Haller, Hermann; Falk, Christine S.; Jonczyk, Rebecca; Lindner, Patrick; Thoms, Stefanie; Siegl, Julia; Mayer, Günter; Feederle, Regina; Blume, Cornelia A. (Basel : MDPI, 2022)
    Chronic antibody-mediated rejection (AMR) is a key limiting factor for the clinical outcome of a kidney transplantation (Ktx), where early diagnosis and therapeutic intervention is needed. This study describes the ...
  • Witt, Martin; Walter, Johanna-Gabriela; Stahl, Frank (Basel : MDPI AG, 2015)
    Microarray technologies are state of the art in biological research, which requires fast genome, proteome and transcriptome analysis technologies. Often antibodies are applied in protein microarrays as proteomic tools. ...
  • Urmann, Katharina (Hannover : Gottfried Wilhelm Leibniz Universität Hannover, 2016)
    [no abstract]
  • Urmann, Katharina; Modrejewski, Julia; Scheper, Thomas; Walter, Johanna-Gabriela (Berlin : Walter de Gruyter, 2017)
    Aptamers are promising alternative binders that can substitute antibodies in various applications. Due to the advantages of aptamers, namely their high affinity, specificity and stability, along with the benefits originating ...
  • Modrejewski, Julia; Walter, Johanna-Gabriela; Kretschmer, Imme; Kemal, Evren; Green, Mark; Belhadj, Hamza; Blume, Cornelia; Scheper, Thomas (Berlin : De Gruyter, 2016)
    The purpose of this study was to develop a model system for targeted drug delivery. This system should enable targeted drug release at a certain tissue in the body. In conventional drug delivery systems, drugs are often ...
  • Prante, Marc (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2021)
    Substances with a low molecular weight (< 900 Da) are classified as small molecules and are ubiquitous in nature and in the human body. Small molecules can be found in the environment where they are produced as secondary ...
  • Prante, Marc; Segal, Ester; Scheper, Thomas; Bahnemann, Janina; Walter, Johanna (Basel : Molecular Diversity Preservation International (MDPI), 2020)
    Aptamers, a group of nucleic acids which can specifically bind to a target molecule, have drawn extensive interest over the past few decades. For analytics, aptamers represent a viable alternative to gold-standard antibodies ...
  • Engelberg, Shira; Modrejewski, Julia; Walter, Johanna-Gabriela; Livney, Yoav D.; Assaraf, Yehuda G. (S.l. : Impact Journals LLC, 2018)
    Lung cancer is the leading cause of cancer mortality worldwide, resulting in 88% deaths of all diagnosed patients. Hence, novel therapeutic modalities are urgently needed. Single-stranded oligonucleotide-based aptamers ...
  • Prante, Marc; Schüling, Torsten; Roth, Bernhard; Bremer, Kort; Walter, Johanna (Basel : MDPI AG, 2019)
    Detection of the small molecule 25-hydroxyvitamin D (25(OH)D) as the most relevant marker for vitamin D supply suffers from a high variability of results using the current detection methods, such as high-performance liquid ...
  • Eilers, Alina (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2021)
    Ein Lateral Flow Assay (LFA) ermöglicht eine schnelle Detektion von Krankheitserregern, Hormonen oder Verunreinigungen. Gleichzeitig sind LFAs kostengünstig und einfach anwendbar, so dass sie auch von nicht fachkundigen ...
  • Arshavsky-Graham, Sofia; Massad-Ivanir, Naama; Paratore, Federico; Scheper, Thomas; Bercovici, Moran; Segal, Ester (Washington D.C. : American Chemical Society, 2017)
    Porous silicon (PSi) nanomaterials have been widely studied as label-free optical biosensors for protein detection. However, these biosensors’ performance, specifically in terms of their sensitivity (which is typically in ...
  • Arshavsky-Graham, Sofia (Hannover : Institutionelles Repositorium der Leibniz Universität Hannover, 2021-08)
    Nanostructured porous silicon (PSi) films have been widely studied for the past two decades as optical transducers for the detection of various molecules, with advantages of simple fabrication, high internal surface, ...
  • Walter, Johanna-Gabriela; Eilers, Alina; Alwis, Lourdes Shanika Malindi; Roth, Bernhard Wilhelm; Bremer, Kort (Basel : MDPI, 2020)
    We present a surface plasmon resonance (SPR) biosensor that is based on a planar-optical multi-mode (MM) polymer waveguide structure applied for the detection of biomolecules in the lower nano-molar (nM) range. The basic ...