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Browsing by Subject "antineoplastic agent"

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Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism

Hartleben, Goetz; Schorpp, Kenji; Kwon, Yun; Betz, Barbara; Tsokanos, Foivos-Filippos; Dantes, Zahra; Schäfer, Arlett; Rothenaigner, Ina; Monroy Kuhn, José Manuel; Morigny, Pauline; Mehr, Lisa; Lin, Sean; Seitz, Susanne; Tokarz, Janina; Artati, Anna; Adamsky, Jerzy; Plettenburg, Oliver; Lutter, Dominik; Irmler, Martin; Beckers, Johannes; Reichert, Maximilian; Hadian, Kamyar; Zeigerer, Anja; Herzig, Stephan; Berriel Diaz, Mauricio (Weinheim : Wiley-VCH, 2021)

By accentuating drug efficacy and impeding resistance mechanisms, combinatorial, multi-agent therapies have emerged as key approaches in the treatment of complex diseases, most notably cancer. Using high-throughput drug ...
An improved synthesis of 4-chlorocoumarin-3-sulfonyl chloride and its reactions with different bidentate nucleophiles to give pyrido[1′, 2′:2,3]- and thiazino[3′,2′:2,3]-1,2,4-thiadiazino[6,5-c] benzopyran-6-one 7,7-dioxides

Jashari, Ahmed; Hey-Hawkins, Evamarie; Mikhova, Bozhana; Draeger, Gerald; Popovski, Emil (Basel : MDPI AG, 2007)

An improved synthetic method affording 4-chlorocoumarin-3-sulfonyl chloride (4) in very good yield (ca. 85 %) is reported. This compound was reacted with various bidentate nucleophiles such as 2-aminopyridines and ...
Plasma response to a single dose of dietary βcryptoxanthin esters from papaya (Carica papaya L.) or non-esterified β-cryptoxanthin in adult human subjects: A comparative study

Breithaupt, Dietmar E.; Weller, Philipp; Wolters, Maike; Hahn, Andreas (Cambridge : Cambridge University Press, 2003)

Many orange-coloured fruits contain β-cryptoxanthin in its non-esterified as well as its esterified form. Information concerning the absorption of β-cryptoxanthin, especially with regard to the metabolism of its fatty acid ...
A systematic review of the cost-effectiveness of targeted therapies for metastatic non-small cell lung cancer (NSCLC)

Lange, Ansgar; Prenzler, Anne; Frank, Martin; Golpon, Heiko; Welte, Tobias; Schulenburg, Johann-Matthias Graf von der (London : BioMed Central Ltd., 2014)

Background: Non-small cell lung cancer (NSCLC) imposes a substantial burden on patients, health care systems and society due to increasing incidence and poor survival rates. In recent years, advances in the treatment of ...
Targeting heat-shock-protein 90 (Hsp90) by natural products: Geldanamycin, a show case in cancer therapy

Franke, Jana; Eichner, Simone; Zeilinger, Carsten; Kirschning, Andreas (Cambridge : Royal Society of Chemistry, 2013)

Covering: 2005 to 2013 In this review recent progress in the development of heat shock proteins (Hsp90) in oncogenesis is illuminated. Particular emphasis is put on inhibitors such as geldanamycin and analogues that serve ...

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Browsing by Subject "antineoplastic agent"

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