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Browsing by Subject "animal model"

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A novel shape memory plate osteosynthesis for noninvasive modulation of fixation stiffness in a rabbit tibia osteotomy model

Müller, Christian W.; Pfeifer, Ronny; Meier, Karen; Decker, Sebastian; Reifenrath, Janin; Gösling, Thomas; Wesling, Volker; Krettek, Christian; Hurschler, Christof; Krämer, Manuel (New York, NY : Hindawi Publishing Corporation, 2015)

Nickel-titanium shape memory alloy (NiTi-SMA) implants might allow modulating fracture healing, changing their stiffness through alteration of both elastic modulus and cross-sectional shape by employing the shape memory ...
Biodegradation of a magnesium alloy implant in the intercondylar femoral notch showed an appropriate response to the synovial membrane in a rabbit model in vivo

Ezechieli, Marco; Diekmann, Julia; Weizbauer, Andreas; Becher, Christoph; Willbold, Elmar; Helmecke, Patrick; Lucas, Arne; Schavan, Robert; Windhagen, Henning (London : SAGE Publications Ltd., 2014)

Degradable magnesium alloys are promising biomaterials for orthopedic applications. The aim of this study was to evaluate the potential effects on both the synovial membrane (synovialis) and the synovial fluid (synovia) ...
Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism

Hartleben, Goetz; Schorpp, Kenji; Kwon, Yun; Betz, Barbara; Tsokanos, Foivos-Filippos; Dantes, Zahra; Schäfer, Arlett; Rothenaigner, Ina; Monroy Kuhn, José Manuel; Morigny, Pauline; Mehr, Lisa; Lin, Sean; Seitz, Susanne; Tokarz, Janina; Artati, Anna; Adamsky, Jerzy; Plettenburg, Oliver; Lutter, Dominik; Irmler, Martin; Beckers, Johannes; Reichert, Maximilian; Hadian, Kamyar; Zeigerer, Anja; Herzig, Stephan; Berriel Diaz, Mauricio (Weinheim : Wiley-VCH, 2021)

By accentuating drug efficacy and impeding resistance mechanisms, combinatorial, multi-agent therapies have emerged as key approaches in the treatment of complex diseases, most notably cancer. Using high-throughput drug ...
Comparison of two prototypes of a magnetically adjustable glaucoma implant in rabbits

Schwerk, Birthe; Harder, Lisa; Windhövel, Claudia; Hewicker-Trautwein, Marion; Wagner, Anna; Bach, Jan-Peter; Voigt, Lena Carolin; Hinze, Ulf; Chichkov, Boris; Haferkamp, Heinz; Lubatschowski, Holger; Nikolic, Stephan; Nolte, Ingo (San Francisco, CA : Public Library of Science (PLoS), 2019)

Glaucoma drainage devices are used in surgical glaucoma therapy. Success of controlling the intraocular pressure is limited due to fibrous implant encapsulation and fibrin coating on the implant which lead to drainage ...
Evaluation of the biological tolerability of the starch-based medical device 4DryField® PH in vitro and in vivo a rat model

Poehnert, Daniel; Abbas, Mahmoud; Maegel, Lavinia; Sambale, Franziska; Lavrentieva, Antonina; Kreipe, Hans-Heinrich; Klempnauer, Jürgen; Winny, Markus (London : SAGE Publications Ltd., 2015)

Purpose To evaluate in vitro cytotoxicity/biocompatibility as well as in vivo tolerability of the novel polysaccharide 4DryField® PH, certified for haemostasis and adhesion prevention. Methods In vitro cytotoxicity/viability ...
First-in-class positron emission tomography tracer for the glucagon receptor

Velikyan, Irina; Haack, Torsten; Bossart, Martin; Evers, Andreas; Laitinen, Ilina; Larsen, Philip; Plettenburg, Oliver; Johansson, Lars; Pierrou, Stefan; Wagner, Michael; Eriksson, Olof (Heidelberg : Springer Verlag, 2019)

Abstract: The glucagon receptor (GCGR) is emerging as an important target in anti-diabetic therapy, especially as part of the pharmacology of dual glucagon-like peptide-1/glucagon (GLP-1/GCG) receptor agonists. However, ...
Free Bioverit® II implants coated with a nanoporous silica layer in a mouse ear model - A histological study

Vogt, Julia C.; Brandes, Gudrun; Ehlert, Nina; Behrens, Peter; Nolte, Ingo; Mueller, Peter P.; Lenarz, Thomas; Stieve, Martin (London : SAGE Publications Ltd., 2009)

The objective of this study is to evaluate the suitability of a mouse middle ear model for testing ossicular replacement materials. Twenty-four BALB/c mice are implanted with the bioglass-ceramic Bioverit® II which is ...
The influence of storage and heat treatment on a magnesium-based implant material: An in vitro and in vivo study

Bracht, Katja; Angrisani, Nina; Seitz, Jan-Marten; Eifler, Rainer; Weizbauer, Andreas; Reifenrath, Janin (London : BioMed Central Ltd., 2015)

Background: Magnesium alloys are recommended as a potential material for osteosynthesis. It is known that storage-induced property modifications can occur in materials like aluminum. Thus the aim of this study was to analyze ...
Intracochlear near infrared stimulation: Feasibility of optoacoustic stimulation in vivo

Baumhoff, Peter; Kallweit, Nicole; Kral, Andrej (Amsterdam : Elsevier B.V., 2019)

Intracochlear optical stimulation has been suggested as an alternative approach to hearing prosthetics in recent years. This study investigated the properties of a near infrared laser (NIR) induced optoacoustic effect. ...
Newcastle disease virus induces testicular damage and disrupts steroidogenesis in specific pathogen free roosters

Rehman, Zaib Ur; Ren, Shanhui; Yang, Bin; Yang, Xiaofeng; Butt, Salman Latif; Afzal, Alia; Malik, Muhammad Irfan; Sun, Yingjie; Yu, Shengqing; Meng, Chunchun; Ding, Chan (London : BioMed Central, 2020)

Newcastle disease (ND), which is caused by Newcastle disease virus (NDV), can cause heavy economic losses to the poultry industry worldwide. It is characterised by extensive pathologies of the digestive, respiratory, and ...
Structural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli

Rueda, Fabian; Céspedes, Maria Virtudes; Sánchez-Chardi, Alejandro; Seras-Franzoso, Joaquin; Pesarrodona, Mireia; Ferrer-Miralles, Neus; Vázquez, Esther; Rinas, Ursula; Unzueta, Ugutz; Mamat, Uwe; Mangues, Ramon; García-Fruitós, Elena; Villaverde, Antonio (London : BioMed Central Ltd., 2016)

Background: Production of recombinant drugs in process-friendly endotoxin-free bacterial factories targets to a lessened complexity of the purification process combined with minimized biological hazards during product ...
Tissue Engineered Skin Substitutes Created by Laser-Assisted Bioprinting Form Skin-Like Structures in the Dorsal Skin Fold Chamber in Mice

Michael, Stefanie; Sorg, Heiko; Peck, Claas-Tido; Koch, Lothar; Deiwick, Andrea; Chichkov, Boris; Vogt, Peter M.; Reimers, Kerstin (San Francisco, California, US : PLOS, 2013)

Tissue engineering plays an important role in the production of skin equivalents for the therapy of chronic and especially burn wounds. Actually, there exists no (cellularized) skin equivalent which might be able to ...

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