Browsing by Subject "Pyrimidines"

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  • Combination therapies induce cancer cell death through the integrated stress response and disturbed pyrimidine metabolism 
    Hartleben, Goetz; Schorpp, Kenji; Kwon, Yun; Betz, Barbara; Tsokanos, Foivos-Filippos; Dantes, Zahra; Schäfer, Arlett; Rothenaigner, Ina; Monroy Kuhn, José Manuel; Morigny, Pauline; Mehr, Lisa; Lin, Sean; Seitz, Susanne; Tokarz, Janina; Artati, Anna; Adamsky, Jerzy; Plettenburg, Oliver; Lutter, Dominik; Irmler, Martin; Beckers, Johannes; Reichert, Maximilian; Hadian, Kamyar; Zeigerer, Anja; Herzig, Stephan; Berriel Diaz, Mauricio (Weinheim : Wiley-VCH, 2021)
    By accentuating drug efficacy and impeding resistance mechanisms, combinatorial, multi-agent therapies have emerged as key approaches in the treatment of complex diseases, most notably cancer. Using high-throughput drug ...
  • Pyrimidine catabolism is required to prevent the accumulation of 5-methyluridine in RNA 
    Gao, Shangyu; Sun, Yu; Chen, Xiaoguang; Zhu, Changhua; Liu, Xiaoye; Wang, Wenlei; Gan, Lijun; Lu, Yanwu; Schaarschmidt, Frank; Herde, Marco; Witte, Claus-Peter; Chen, Mingjia (Oxford : Oxford Univ. Press, 2023)
    5-Methylated cytosine is a frequent modification in eukaryotic RNA and DNA influencing mRNA stability and gene expression. Here we show that free 5-methylcytidine (5mC) and 5-methyl-2′-deoxycytidine are generated from ...