Browsing by Subject "Mutasynthesis"

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Darstellung neuer Ansamycin-Derivate über Mutasynthese in Kombination mit Semisynthese

Eichner, Simone (Hannover : Gottfried Wilhelm Leibniz Universität Hannover, 2011)

[no abstract]
Muta- und semisynthetische Zugänge zu Konjugaten aus Ansamitocinen und Tumor-assoziierten Liganden

Mancuso, Lena (Hannover : Gottfried Wilhelm Leibniz Universität Hannover, 2014)

[no abstract]
Preparation of new alkyne-modified ansamitocins by mutasynthesis

Harmrolfs, Kirsten; Mancuso, Lena; Drung, Binia; Sasse, Florenz; Kirschning, Andreas (Frankfurt am Main : Beilstein-Institut zur Förderung der Chemischen Wissenschaften, 2014)

The preparation of alkyne-modified ansamitocins by mutasynthetic supplementation of Actinosynnema pretiosum mutants with alkyne-substituted aminobenzoic acids is described. This modification paved the way to introduce a ...
Unprecedented deoxygenation at C-7 of the ansamitocin core during mutasynthetic biotransformations

Knobloch, Tobias; Draeger, Gerald; Collisi, Wera; Sasse, Florenz; Kirschning, Andreas (Frankfurt am Main : Beilstein-Institut Zur Förderung der Chemischen Wissenschaften, 2012)

We describe the unprecedented formation of six ansamitocin derivatives that are deoxygenated at C-7 of the ansamitocin core, obtained during fermentation experiments by employing a variety of Actinosynnema pretiosum mutants ...

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