Auflistung nach Schlagwort "Metabolites"

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  • Continuous optical in-line glucose monitoring and control in CHO cultures contributes to enhanced metabolic efficiency while maintaining darbepoetin alfa product quality 
    Lederle, Mario; Tric, Mircea; Roth, Tatjana; Schütte, Lina; Rattenholl, Anke; Lütkemeyer, Dirk; Wölfl, Stefan; Werner, Tobias; Wiedemann, Philipp (Weinheim : Wiley-VCH, 2021)
    Great efforts are directed towards improving productivity, consistency and quality of biopharmaceutical processes and products. One particular area is the development of new sensors for continuous monitoring of critical ...
  • The cycloaspeptides: Uncovering a new model for methylated nonribosomal peptide biosynthesis 
    De Mattos-Shipley, Kate M.J.; Greco, Claudio; Heard, David M.; Hough, Gemma; Mulholland, Nicholas P.; Vincent, Jason L.; Micklefield, Jason; Simpson, Thomas J.; Willis, Christine L.; Cox, Russell J.; Bailey, Andrew M. (Cambridge : Royal Society of Chemistry, 2018)
    The cycloaspeptides are bioactive pentapeptides produced by various filamentous fungi, which have garnered interest from the agricultural industry due to the reported insecticidal activity of the minor metabolite, ...
  • Cyclopropanol Warhead in Malleicyprol Confers Virulence of Human- and Animal-Pathogenic Burkholderia Species 
    Trottmann, Felix; Franke, Jakob; Richter, Ingrid; Ishida, Keishi; Cyrulies, Michael; Dahse, Hans-Martin; Regestein, Lars; Hertweck, Christian (Weinheim : Wiley-VCH Verlag, 2019)
    Burkholderia species such as B. mallei and B. pseudomallei are bacterial pathogens causing fatal infections in humans and animals (glanders and melioidosis), yet knowledge on their virulence factors is limited. While ...
  • Heterologous Production of Fungal Maleidrides Reveals the Cryptic Cyclization Involved in their Biosynthesis 
    Williams, Katherine; Szwalbe, Agnieszka J.; Mulholland, Nicholas P.; Vincent, Jason L.; Bailey, Andrew M.; Willis, Christine L.; Simpson, Thomas J.; Cox, Russell J. (Weinheim : Wiley-VCH Verlag, 2016)
    Fungal maleidrides are an important family of bioactive secondary metabolites that consist of 7, 8, or 9-membered carbocycles with one or two fused maleic anhydride moieties. The biosynthesis of byssochlamic acid (a ...
  • Uncovering biosynthetic relationships between antifungal nonadrides and octadrides 
    De Mattos-Shipley, Kate M. J.; Spencer, Catherine E.; Greco, Claudio; Heard, David M.; O'Flynn, Daniel E.; Dao, Trong T.; Song, Zhongshu; Mulholland, Nicholas P.; Vincent, Jason L.; Simpson, Thomas J.; Cox, Russell J.; Bailey, Andrew M.; Willis, Christine L. (Cambridge : RSC, 2020)
    Maleidrides are a class of bioactive secondary metabolites unique to filamentous fungi, which contain one or more maleic anhydrides fused to a 7-, 8- or 9- membered carbocycle (named heptadrides, octadrides and nonadrides ...