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Characterisation of the biosynthetic pathway to agnestins A and B reveals the reductive route to chrysophanol in fungi

Szwalbe, Agniezka J.; Williams, Katherine; Song, Zhongshu; De Mattos-Shipley, Kate M.J.; Vincent, Jason L.; Bailey, Andrew M.; Willis, Christine L.; Cox, Russell J.; Simpson, Thomas J. (Cambridge : Royal Society of Chemistry, 2019)

Two new dihydroxy-xanthone metabolites, agnestins A and B, were isolated from Paecilomyces variotii along with a number of related benzophenones and xanthones including monodictyphenone. The structures were elucidated by ...
Continuous flow chemistry: a discovery tool for new chemical reactivity patterns

Hartwig, Jan; Metternich, Jan B.; Nikbin, Nikzad; Kirschning, Andreas; Ley, Steven V. (Cambridge : Royal Society of Chemistry, 2014-04-17)

Continuous flow chemistry as a process intensification tool is well known. However, its ability to enable chemists to perform reactions which are not possible in batch is less well studied or understood. Here we present ...
Cyclopropanol Warhead in Malleicyprol Confers Virulence of Human- and Animal-Pathogenic Burkholderia Species

Trottmann, Felix; Franke, Jakob; Richter, Ingrid; Ishida, Keishi; Cyrulies, Michael; Dahse, Hans-Martin; Regestein, Lars; Hertweck, Christian (Weinheim : Wiley-VCH Verlag, 2019)

Burkholderia species such as B. mallei and B. pseudomallei are bacterial pathogens causing fatal infections in humans and animals (glanders and melioidosis), yet knowledge on their virulence factors is limited. While ...
Development of the Synthesis of Desepoxy-Tedanolide C

Lücke, Daniel; Kalesse, Markus ([Erscheinungsort nicht ermittelbar] : American Chemical Society, 2024)

We are presenting the development of our route for the total synthesis of desepoxy-tedanolide C. Through the obtained analytical data, the proposed structure of tedanolide C is questioned and a different configuration for ...
Heterologous Production of Fungal Maleidrides Reveals the Cryptic Cyclization Involved in their Biosynthesis

Williams, Katherine; Szwalbe, Agnieszka J.; Mulholland, Nicholas P.; Vincent, Jason L.; Bailey, Andrew M.; Willis, Christine L.; Simpson, Thomas J.; Cox, Russell J. (Weinheim : Wiley-VCH Verlag, 2016)

Fungal maleidrides are an important family of bioactive secondary metabolites that consist of 7, 8, or 9-membered carbocycles with one or two fused maleic anhydride moieties. The biosynthesis of byssochlamic acid (a ...
Investigation of chain-length selection by the tenellin iterative highly-reducing polyketide synthase

Schmidt, Katharina; Cox, Russell J. (London : RSC Publishing, 2024)

The programming of widely distributed iterative fungal hr-PKS is mysterious, yet it is central for generating polyketide natural product diversity by controlling the chain length, β-processing level and methylation patterns ...
Miniaturized high-performance drift tube ion mobility spectrometer

Ahrens, André; Hitzemann, Moritz; Zimmermann, Stefan (Heidelberg : Springer Verlag, 2019)

Developing powerful hand-held drift tube ion mobility spectrometers (IMS) requires small, lightweight drift tubes with high analytical performance. In this work, we present an easy-to-manufacture, miniaturized drift tube ...
Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase

Yang, Xiao-Long; Friedrich, Steffen; Yin, Sen; Piech, Oliver; Williams, Katherine; Simpson, Thomas J.; Cox, Russell J. (Cambridge : Royal Society of Chemistry, 2019)

Exchange of 32 different sub-fragments of the C-methyltransferase (C-MeT), pseudo-ketoreductase (ΨKR) and ketoreductase (KR) catalytic domains of the tenellin iterative Type I polyketide synthase non ribosomal peptide ...
Oxidative azidations of phenols and ketones using iodine azide after release from an ion exchange resin

Kösel, Teresa; Dräger, Gerald; Kirschning, Andreas (Cambridge : Royal Society of Chemistry, 2021)

The oxidative oligoazidation of phenols and ketones using iodine azide (IN3) provided by its release from an ion exchange resin is reported. Preliminary mechanistic studies indicate a previously unknown reactivity of iodine ...
Substrate selectivity of an isolated enoyl reductase catalytic domain from an iterative highly reducing fungal polyketide synthase reveals key components of programming

Roberts, Douglas M.; Bartel, Christoph; Scott, Alan; Ivison, David; Simpson, Thomas J.; Cox, Russell J. (Cambridge : Royal Society of Chemistry, 2017)

A cis-acting enoyl reductase (ER) catalytic domain was isolated from a fungal highly reducing iterative polyketide synthase (HR-iPKS) for the first time and studied in vitro. The ER from the squalestatin tetraketide synthase ...
Towards a hand-held, fast, and sensitive gas chromatograph-ion mobility spectrometer for detecting volatile compounds

Ahrens, André; Zimmermann, Stefan (Berlin [u.a.] : Springer, 2020)

Ion mobility spectrometers can detect gaseous compounds at atmospheric pressure in the range of parts per trillion within a second. Due to their fast response times, high sensitivity, and limited instrumental effort, they ...

Now showing items 1-11 of 11

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