[no abstract]

The ansamycin antibiotic geldanamycin is biosynthesized by Streptomyces hygroscopicus through a PKS type I. The macrolactamization in the biosynthesis is catalyzed by the amide synthase GdmF. GdmF belongs to the superfamily ...

The effect of various natural products and chemical compounds to their corresponding molecular target is often unidentified. Drugs are effective by binding to a molecule (the target) and inhibiting its function. In order ...