Browsing by Subject "Dose-Response Relationship, Drug"

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Antibiotic Conjugates with an Artificial MECAM-Based Siderophore Are Potent Agents against Gram-Positive and Gram-Negative Bacterial Pathogens

Pinkert, Lukas; Lai, Yi-Hui; Peukert, Carsten; Hotop, Sven-Kevin; Karge, Bianka; Schulze, Lara Marie; Grunenberg, Jörg; Brönstrup, Mark (Washington, DC : ACS, 2021)

The development of novel drugs against Gram-negative bacteria represents an urgent medical need. To overcome their outer cell membrane, we synthesized conjugates of antibiotics and artificial siderophores based on the MECAM ...
Evaluation of incidence rates in pre-clinical studies using a williams-type procedure

Hothorn, Ludwig A.; Sill, Martin; Schaarschmidt, Frank (Berlin : De Gruyter, 2010)

The analysis of dose-response relationships is a common problem in pre-clinical studies. For example, proportions such as mortality rates and histopathological findings are of particular interest in repeated toxicity ...
Stable Insertion of the Early Light-induced Proteins into Etioplast Membranes Requires Chlorophyll a

Adamska, Iwona; Kruse, Elisabeth; Kloppstech, Klaus (Bethesda, Md. : ASBMB Publications, 2000)

Etiolated plant seedlings exposed to light respond by transient accumulation of the nucleus-encoded, plastid-located early light-inducible proteins (Elips). These proteins are distant relatives of the light-harvesting ...

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